HCSGD entry for PAK3
1. General information
| Official gene symbol | PAK3 |
|---|---|
| Entrez ID | 5063 |
| Gene full name | p21 protein (Cdc42/Rac)-activated kinase 3 |
| Other gene symbols | CDKN1A MRX30 MRX47 OPHN3 PAK3beta bPAK hPAK3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IDA | biological_process |
| GO:0000187 | Activation of MAPK activity | IDA | biological_process |
| GO:0000278 | Mitotic cell cycle | IBA | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004702 | Receptor signaling protein serine/threonine kinase activity | IBA | molecular_function |
| GO:0004708 | MAP kinase kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0007165 | Signal transduction | IBA | biological_process |
| GO:0007409 | Axonogenesis | IBA IEA ISS | biological_process |
| GO:0016358 | Dendrite development | IEA ISS | biological_process |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0023014 | Signal transduction by phosphorylation | IBA | biological_process |
| GO:0030833 | Regulation of actin filament polymerization | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | IBA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050808 | Synapse organization | TAS | biological_process |
| GO:0060997 | Dendritic spine morphogenesis | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8564743361 | 0.1894753391 | 0.9999902473 | 0.8439973600 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1392872975 |
| GSE13712_SHEAR | Up | 0.0556409972 |
| GSE13712_STATIC | Down | -0.0178054042 |
| GSE19018 | Down | -0.0000881326 |
| GSE19899_A1 | Up | 0.0865688171 |
| GSE19899_A2 | Down | -0.3064378980 |
| PubMed_21979375_A1 | Up | 0.0491416298 |
| PubMed_21979375_A2 | Down | -0.2701072709 |
| GSE35957 | Down | -0.3786871166 |
| GSE36640 | Down | -0.2090284444 |
| GSE54402 | Down | -0.1401154385 |
| GSE9593 | Down | -0.0767826945 |
| GSE43922 | Up | 0.0159224507 |
| GSE24585 | Up | 0.4886980929 |
| GSE37065 | Down | -0.6534683382 |
| GSE28863_A1 | Down | -0.2950471125 |
| GSE28863_A2 | Down | -0.0182085336 |
| GSE28863_A3 | Up | 0.1212069515 |
| GSE28863_A4 | Up | 0.1666944310 |
| GSE48662 | Down | -0.2176078535 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018369 | Microarray | Functional MTI (Weak) | 18185580 |
Entries Per Page
Displaying Page of
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | NA | hsa-miR-21 | 17991735 | |||
| hsa-miR-106a-5p | MIMAT0000103 | NA | hsa-miR-106a | {Western blot} | {overexpression by miRNA mimics tranfection} | 19782699 | |
| hsa-miR-93-5p | MIMAT0000093 | NA | hsa-miR-93 | {Western blot} | {overexpression by miRNA mimics tranfection} | 19422085 | |
| hsa-miR-106b-5p | MIMAT0000680 | NA | hsa-miR-106b | {Western blot} | {overexpression by miRNA mimics tranfection} | 19422085 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
