HCSGD entry for PAK2

1. General information

Official gene symbolPAK2
Entrez ID5062
Gene full namep21 protein (Cdc42/Rac)-activated kinase 2
Other gene symbolsPAK65 PAKgamma
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleIBAbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEA TASmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006469Negative regulation of protein kinase activityTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007409AxonogenesisIBAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016310PhosphorylationIDAbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0023014Signal transduction by phosphorylationIBAbiological_process
GO:0030036Actin cytoskeleton organizationIBAbiological_process
GO:0030296Protein tyrosine kinase activator activityIDAmolecular_function
GO:0031295T cell costimulationTASbiological_process
GO:0035556Intracellular signal transductionIBAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0040008Regulation of growthIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processIMP TASbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050690Regulation of defense response to virus by virusTASbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityIDAbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIMPbiological_process
GO:2001271Negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40512682270.63646075760.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1541580446
GSE13712_SHEARUp0.0024684771
GSE13712_STATICDown-0.1853062995
GSE19018Down-0.0719443614
GSE19899_A1Down-0.0335760720
GSE19899_A2Up0.4231751159
PubMed_21979375_A1Down-0.1345852762
PubMed_21979375_A2Up0.5163082486
GSE35957Up0.3365623965
GSE36640Down-0.1032033930
GSE54402Up0.1848650064
GSE9593Up0.0270531565
GSE43922Up0.0351683999
GSE24585Down-0.1230088264
GSE37065Down-0.1549225917
GSE28863_A1Up0.0218646761
GSE28863_A2Up0.1029409617
GSE28863_A3Up0.2835138606
GSE28863_A4Down-0.1186657543
GSE48662Down-0.4290217850

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020989Reporter assay;OtherFunctional MTI20584899
hsa-miR-500a-3pMIMAT0002871MIRT041157CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041405CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.