HCSGD entry for ITSN2
1. General information
| Official gene symbol | ITSN2 |
|---|---|
| Entrez ID | 50618 |
| Gene full name | intersectin 2 |
| Other gene symbols | PRO2015 SH3D1B SH3P18 SWA SWAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006897 | Endocytosis | IEA | biological_process |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2994169826 | 0.8441670833 | 0.9987484603 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1391793928 |
| GSE13712_SHEAR | Up | 0.2240544515 |
| GSE13712_STATIC | Up | 0.0016228019 |
| GSE19018 | Up | 0.0658369918 |
| GSE19899_A1 | Down | -0.0438357595 |
| GSE19899_A2 | Down | -0.0237486633 |
| PubMed_21979375_A1 | Up | 0.3096792218 |
| PubMed_21979375_A2 | Up | 0.1111172165 |
| GSE35957 | Up | 0.0074833224 |
| GSE36640 | Up | 0.2348040796 |
| GSE54402 | Down | -0.0013815326 |
| GSE9593 | Up | 0.0794871019 |
| GSE43922 | Down | -0.0512596617 |
| GSE24585 | Down | -0.3838482574 |
| GSE37065 | Up | 0.1600098106 |
| GSE28863_A1 | Up | 0.1879531577 |
| GSE28863_A2 | Up | 0.2703837164 |
| GSE28863_A3 | Up | 0.3578649874 |
| GSE28863_A4 | Up | 0.0475037451 |
| GSE48662 | Up | 0.1925776761 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019375 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022783 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030879 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-320c | MIMAT0005793 | MIRT036170 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044995 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045590 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26439691 | ING1a induces expression of intersectin 2, a scaffold protein necessary for endocytosis, altering the stoichiometry of endocytosis proteins, subsequently blocking growth factor uptake leading to activation of Rb signaling to block cell growth |
| 23472054 | Intersectin 2 (ITSN2) is most affected by ING1a, being rapidly induced >25-fold |
| 23472054 | Overexpression of ITSN2 independently induces expression of the p16 and p57(KIP2) cyclin-dependent kinase inhibitors, which act to block Rb inactivation, acting as downstream effectors of ING1a |
| 23472054 | ITSN2 is also induced in normally senescing cells, consistent with elevated levels of ING1a inducing ITSN2 as part of a normal senescence program |
| 23472054 | Knockdown of ITSN2 also blocks the ability of ING1a to induce a senescent phenotype, confirming that ITSN2 is a major transducer of ING1a-induced senescence signaling |
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