HCSGD entry for PRDX1
1. General information
| Official gene symbol | PRDX1 |
|---|---|
| Entrez ID | 5052 |
| Gene full name | peroxiredoxin 1 |
| Other gene symbols | MSP23 NKEF-A NKEFA PAG PAGA PAGB PRX1 PRXI TDPX2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0004601 | Peroxidase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005719 | Nuclear euchromatin | IEA | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0005782 | Peroxisomal matrix | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0008379 | Thioredoxin peroxidase activity | IDA | molecular_function |
| GO:0019430 | Removal of superoxide radicals | IEA | biological_process |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0032872 | Regulation of stress-activated MAPK cascade | IEA | biological_process |
| GO:0034101 | Erythrocyte homeostasis | IEA | biological_process |
| GO:0042267 | Natural killer cell mediated cytotoxicity | IEA | biological_process |
| GO:0042345 | Regulation of NF-kappaB import into nucleus | IEA | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0042744 | Hydrogen peroxide catabolic process | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2383444018 | 0.7985522473 | 0.9241990277 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6592528360 |
| GSE13712_SHEAR | Up | 0.2390339024 |
| GSE13712_STATIC | Up | 0.1621816323 |
| GSE19018 | Up | 0.0644150883 |
| GSE19899_A1 | Up | 0.0193688260 |
| GSE19899_A2 | Down | -0.1272837583 |
| PubMed_21979375_A1 | Up | 0.2092580944 |
| PubMed_21979375_A2 | Down | -0.2301146780 |
| GSE35957 | Up | 0.0693847656 |
| GSE36640 | Up | 0.3629681017 |
| GSE54402 | Up | 0.4146235055 |
| GSE9593 | Up | 0.1114862616 |
| GSE43922 | Up | 0.0652885058 |
| GSE24585 | Down | -0.0605752165 |
| GSE37065 | Up | 0.0867326994 |
| GSE28863_A1 | Down | -0.1946734137 |
| GSE28863_A2 | Up | 0.0248476114 |
| GSE28863_A3 | Down | -0.1303961713 |
| GSE28863_A4 | Down | -0.1126686361 |
| GSE48662 | Down | -0.1207053664 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019836 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025797 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1225-3p | MIMAT0005573 | MIRT036544 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040747 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041864 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046315 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048535 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23933099 | Interestingly, we found an increased amount of intracellular ROS in these cells, which was accompanied by elevated expression of catalase and peroxiredoxin-1 |
| 19126595 | This was associated with increased expression of peroxiredoxin 1 (P<0 |
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