HCSGD entry for DEC1

1. General information

Official gene symbolDEC1
Entrez ID50514
Gene full namedeleted in esophageal cancer 1
Other gene symbolsCTS9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0008285Negative regulation of cell proliferationTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40777377000.92210868510.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0782689982
GSE13712_SHEARDown-0.0416769794
GSE13712_STATICUp0.1155408367
GSE19018Up0.1015979617
GSE19899_A1Up0.2261428559
GSE19899_A2Up0.2016135220
PubMed_21979375_A1Down-0.0130356569
PubMed_21979375_A2Up0.1437510984
GSE35957Down-0.0568950995
GSE36640Up0.1138536297
GSE54402Down-0.1295484316
GSE9593Up0.0644041159
GSE43922Up0.0135658186
GSE24585Down-0.0013746766
GSE37065Up0.0883434500
GSE28863_A1Down-0.1123754562
GSE28863_A2Up0.1534225249
GSE28863_A3Up0.2698044822
GSE28863_A4Up0.0635664939
GSE48662Down-0.0304227132

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030072MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25355277MSCs were treated with high glucose (HG) in order to induce senescence, which was markedly attenuated by pre-treatment with isosorbide dinitrate (ISDN), a commonly used nitrate, as indicated by senescence-associated galactosidase (SA-beta-gal) activity, p21 expression, as well as by the mRNA levels of DNA methyltransferase 1 (DNMT1) and differentiated embryo chondrocyte expressed gene 1 (DEC1), which are senescence-related biomarkers
24626611A variety of senescence-associated biomarkers including cathepsin D (CD), the eukaryotic translation elongation factors eEF1A1, eEF1B2, decoy receptor 2 and Dec1 were further validated in vivo or in vitro
23982736We show that low doses of metformin induced hepatoma cell senescence characterized by accumulation of senescence-associated beta-galactosidase activity (SA-beta-gal) and the senescence marker Dec1, whereas the higher doses initiated apoptotic cell death
23578198Importantly, in vivo study showed tumor growth inhibition and prolonged overall survival were associated with increased p53 and Dec1 expression, decreased Raf-1 and Ki67 staining, and upregulated SA-beta-gal activity after sunitinib treatment
22844531Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma
22844531Human differentiated embryo chondrocyte expressed gene 1 (Dec1) is an important transcription factor that related to senescence
22844531In this study, DEC1 immunohistochemical analysis was performed on tissue microarray blocks constructed from ESCC combined with adjacent precursor tissues of 241 patients
22844531Compared with normal epithelia, DEC1 expression was significantly increased in intraepithelial neoplasia and DEC1 expression was significantly decreased in ESCC in comparison with intraepithelial neoplasia
22844531In vitro, DEC1 overexpression induced cellular senescence, and it inhibited cell growth and colony formation in ESCC cell line EC9706
22844531Fresh esophagectomy tissue sections from five ESCC patients were detected by immunohistochemistry of DEC1 and senescence-associated beta-galactosidase (SA-beta-Gal) activity, and strongly positive expression of DEC1 was correlated to more senescent cells in these fresh tissue sections
22844531Kaplan-Meier method analysis of the 241 patients revealed that DEC1 expression levels were significantly correlated with the survival of ESCC patients after surgery
22844531The expression levels of DEC1 were also correlated with age, tumor embolus, depth of invasion of ESCC, lymph metastasis status and pTNMs
22844531These results suggest that DEC1 overexpression in precursor lesions of ESCC is a protective mechanism by inducing cellular senescence in ESCC initiation, and DEC1 may be a potential prognostic marker of ESCC
21749859Our results show that GAPDH-depleted cells establish senescence phenotype, as revealed by proliferation arrest, changes in morphology, SA-beta-galactosidase staining, and more than 2-fold up-regulation of senescence-associated genes DEC1 and GLB1
18025081DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
18025081Among the many candidates is DEC1, a basic helix-loop-helix transcription factor that has been recently shown to be up-regulated in K-ras-induced premature senescence
18025081However, it is not clear whether DEC1 is capable of inducing senescence
18025081Here, we found that DEC1 is a novel target gene of the p53 family and mediates p53-dependent premature senescence
18025081Specifically, we showed that DEC1 is induced by the p53 family and DNA damage in a p53-dependent manner
18025081We also found that the p53 family proteins bind to, and activate, the promoter of the DEC1 gene
18025081In addition, we showed that overexpression of DEC1 induces G(1) arrest and promotes senescence
18025081Taken together, our data provided strong evidence that DEC1 is one of the effectors downstream of p53 to promote premature senescence
Entries Per Page
Displaying Page of