HCSGD entry for RRM2B

1. General information

Official gene symbolRRM2B
Entrez ID50484
Gene full nameribonucleotide reductase M2 B (TP53 inducible)
Other gene symbolsMTDPS8A MTDPS8B P53R2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIEAbiological_process
GO:0003014Renal system processIEAbiological_process
GO:0004748Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006264Mitochondrial DNA replicationIEAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0006979Response to oxidative stressIEAbiological_process
GO:0009186Deoxyribonucleoside diphosphate metabolic processIEAbiological_process
GO:0009200Deoxyribonucleoside triphosphate metabolic processIEAbiological_process
GO:0009263Deoxyribonucleotide biosynthetic processIEAbiological_process
GO:0015949Nucleobase-containing small molecule interconversionTASbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:1902254Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00025857680.95762885150.04448366011.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5879240410
GSE13712_SHEARUp0.4832478734
GSE13712_STATICUp0.6633949385
GSE19018Up1.7164889628
GSE19899_A1Up1.2510344680
GSE19899_A2Up1.2930076127
PubMed_21979375_A1Up1.2404052625
PubMed_21979375_A2Up1.1073889707
GSE35957Up0.3198998934
GSE36640Up2.1071487691
GSE54402Up0.1259400188
GSE9593Up0.2780934043
GSE43922Up0.7074477850
GSE24585Up0.5673066655
GSE37065Up0.5188872551
GSE28863_A1Down-0.3458665687
GSE28863_A2Down-0.0053083667
GSE28863_A3Down-1.1820679620
GSE28863_A4Up0.2568776867
GSE48662Up0.5983437945

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-142-3pMIMAT0000434MIRT021612MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.