HCSGD entry for PAFAH1B1

1. General information

Official gene symbolPAFAH1B1
Entrez ID5048
Gene full nameplatelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Other gene symbolsLIS1 LIS2 MDCR MDS PAFAH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000132Establishment of mitotic spindle orientationIMPbiological_process
GO:0000226Microtubule cytoskeleton organizationIEA ISSbiological_process
GO:0000235Astral microtubuleIDAcellular_component
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000776KinetochoreIDAcellular_component
GO:0001667Ameboidal cell migrationIEAbiological_process
GO:0001675Acrosome assemblyIEA ISSbiological_process
GO:0001764Neuron migrationIEA IMP ISSbiological_process
GO:0001961Positive regulation of cytokine-mediated signaling pathwayIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005635Nuclear envelopeIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDA IEA ISScellular_component
GO:0005829CytosolIEA ISS TAScellular_component
GO:0005871Kinesin complexIEAcellular_component
GO:0005875Microtubule associated complexIDAcellular_component
GO:0005938Cell cortexIDAcellular_component
GO:0007017Microtubule-based processIDAbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007097Nuclear migrationIEAbiological_process
GO:0007268Synaptic transmissionIEA ISSbiological_process
GO:0007405Neuroblast proliferationIEA ISSbiological_process
GO:0007611Learning or memoryIEA ISSbiological_process
GO:0008017Microtubule bindingIEA ISSmolecular_function
GO:0008090Retrograde axon cargo transportIEA ISSbiological_process
GO:0008201Heparin bindingISSmolecular_function
GO:0008344Adult locomotory behaviorIEA IMPbiological_process
GO:0009306Protein secretionIEAbiological_process
GO:0010977Negative regulation of neuron projection developmentIEAbiological_process
GO:0016042Lipid catabolic processIEAbiological_process
GO:0016787Hydrolase activityIEAmolecular_function
GO:0017145Stem cell divisionIEAbiological_process
GO:0019226Transmission of nerve impulseISSbiological_process
GO:0021540Corpus callosum morphogenesisIMPbiological_process
GO:0021766Hippocampus developmentIEA ISSbiological_process
GO:0021819Layer formation in cerebral cortexIEA ISSbiological_process
GO:0021895Cerebral cortex neuron differentiationIEAbiological_process
GO:0021987Cerebral cortex developmentIMPbiological_process
GO:0030036Actin cytoskeleton organizationIEA ISSbiological_process
GO:0030426Growth coneIEAcellular_component
GO:0031023Microtubule organizing center organizationIMPbiological_process
GO:0031252Cell leading edgeIEA ISScellular_component
GO:0031512Motile primary ciliumIEA ISScellular_component
GO:0031513Nonmotile primary ciliumISScellular_component
GO:0031965Nuclear membraneIEAcellular_component
GO:0031982VesicleIEAcellular_component
GO:0032319Regulation of Rho GTPase activityIEA ISSbiological_process
GO:0034452Dynactin bindingISSmolecular_function
GO:0036035Osteoclast developmentIEAbiological_process
GO:0042803Protein homodimerization activityIEA ISSmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043274Phospholipase bindingISSmolecular_function
GO:0045502Dynein bindingIDAmolecular_function
GO:0045505Dynein intermediate chain bindingIEAmolecular_function
GO:0045773Positive regulation of axon extensionIEAbiological_process
GO:0045931Positive regulation of mitotic cell cycleIEAbiological_process
GO:0046329Negative regulation of JNK cascadeIEAbiological_process
GO:0046469Platelet activating factor metabolic processISSbiological_process
GO:0047496Vesicle transport along microtubuleIEA ISSbiological_process
GO:0048471Perinuclear region of cytoplasmIEA ISScellular_component
GO:0048854Brain morphogenesisIMPbiological_process
GO:0050885Neuromuscular process controlling balanceIEA IMPbiological_process
GO:0051081Nuclear envelope disassemblyIEAbiological_process
GO:0051219Phosphoprotein bindingIEA ISSmolecular_function
GO:0051660Establishment of centrosome localizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70739379960.30863519240.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3918992004
GSE13712_SHEARUp0.0715079213
GSE13712_STATICDown-0.0356074842
GSE19018Up0.1695856134
GSE19899_A1Down-0.2777760998
GSE19899_A2Down-0.0888379398
PubMed_21979375_A1Down-0.6208863475
PubMed_21979375_A2Up0.3534021973
GSE35957Up0.1993625444
GSE36640Up0.3992452976
GSE54402Down-0.1373467213
GSE9593Up0.2174538194
GSE43922Down-0.0057010709
GSE24585Up0.1497693475
GSE37065Up0.0205860154
GSE28863_A1Up0.1470994864
GSE28863_A2Down-0.1114038657
GSE28863_A3Down-0.2291342392
GSE28863_A4Down-0.0796855651
GSE48662Down-0.0731652468

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT020051MicroarrayFunctional MTI (Weak)20215506
hsa-miR-215-5pMIMAT0000272MIRT024898MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026749MicroarrayFunctional MTI (Weak)19074876
hsa-miR-101-3pMIMAT0000099MIRT027380SequencingFunctional MTI (Weak)20371350
hsa-miR-18a-5pMIMAT0000072MIRT031314SequencingFunctional MTI (Weak)20371350
hsa-miR-100-5pMIMAT0000098MIRT048588CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.