HCSGD entry for PCSK6
1. General information
| Official gene symbol | PCSK6 |
|---|---|
| Entrez ID | 5046 |
| Gene full name | proprotein convertase subtilisin/kexin type 6 |
| Other gene symbols | PACE4 SPC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004175 | Endopeptidase activity | IDA | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IDA IEA | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007354 | Zygotic determination of anterior/posterior axis, embryo | IEA | biological_process |
| GO:0007368 | Determination of left/right symmetry | IEA | biological_process |
| GO:0008201 | Heparin binding | IDA | molecular_function |
| GO:0009100 | Glycoprotein metabolic process | IDA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016485 | Protein processing | IDA | biological_process |
| GO:0016486 | Peptide hormone processing | IDA | biological_process |
| GO:0030510 | Regulation of BMP signaling pathway | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0032455 | Nerve growth factor processing | TAS | biological_process |
| GO:0032902 | Nerve growth factor production | IDA | biological_process |
| GO:0032940 | Secretion by cell | IDA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048406 | Nerve growth factor binding | IDA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4269625926 | 0.9463340869 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0173829896 |
| GSE13712_SHEAR | Up | 0.0587298218 |
| GSE13712_STATIC | Up | 0.0440817925 |
| GSE19018 | Up | 0.0726682053 |
| GSE19899_A1 | Up | 0.0495369994 |
| GSE19899_A2 | Down | -0.0397959873 |
| PubMed_21979375_A1 | Up | 0.0602306764 |
| PubMed_21979375_A2 | Down | -0.0786065654 |
| GSE35957 | Up | 0.0673781352 |
| GSE36640 | Up | 0.3781507163 |
| GSE54402 | Down | -0.0262967072 |
| GSE9593 | Up | 0.0499487826 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.2153102184 |
| GSE28863_A2 | Up | 0.0622384181 |
| GSE28863_A3 | Up | 0.2797715749 |
| GSE28863_A4 | Up | 0.1004189165 |
| GSE48662 | Up | 0.5356056237 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-454-3p | MIMAT0003885 | MIRT039239 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
