HCSGD entry for FURIN

1. General information

Official gene symbolFURIN
Entrez ID5045
Gene full namefurin (paired basic amino acid cleaving enzyme)
Other gene symbolsFUR PACE PCSK3 SPC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002020Protease bindingIPImolecular_function
GO:0004175Endopeptidase activityIDAmolecular_function
GO:0004252Serine-type endopeptidase activityIDA IEAmolecular_function
GO:0004867Serine-type endopeptidase inhibitor activityIDAmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006465Signal peptide processingIDAbiological_process
GO:0006508ProteolysisIEA TASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0008283Cell proliferationIMPbiological_process
GO:0009966Regulation of signal transductionIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010466Negative regulation of peptidase activityIDAbiological_process
GO:0010951Negative regulation of endopeptidase activityIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processTASbiological_process
GO:0016485Protein processingIDA IEA IMPbiological_process
GO:0016486Peptide hormone processingIDAbiological_process
GO:0017187Peptidyl-glutamic acid carboxylationTASbiological_process
GO:0019058Viral life cycleIEPbiological_process
GO:0019068Virion assemblyTASbiological_process
GO:0019082Viral protein processingTASbiological_process
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030140Trans-Golgi network transport vesicleIDAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0032455Nerve growth factor processingTASbiological_process
GO:0032804Negative regulation of low-density lipoprotein particle receptor catabolic processIDAbiological_process
GO:0032902Nerve growth factor productionIDAbiological_process
GO:0032904Negative regulation of nerve growth factor productionIDAbiological_process
GO:0032911Negative regulation of transforming growth factor beta1 productionIMPbiological_process
GO:0032940Secretion by cellIDAbiological_process
GO:0042176Regulation of protein catabolic processIMPbiological_process
GO:0042277Peptide bindingIDAmolecular_function
GO:0043043Peptide biosynthetic processIDAbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048406Nerve growth factor bindingIDAmolecular_function
GO:0051044Positive regulation of membrane protein ectodomain proteolysisICbiological_process
GO:0052548Regulation of endopeptidase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02388202960.85840680830.36631637531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0288597030
GSE13712_SHEARUp0.1596048753
GSE13712_STATICDown-0.0733353762
GSE19018Up0.0488793237
GSE19899_A1Up0.1983920592
GSE19899_A2Up0.4671223184
PubMed_21979375_A1Down-0.1251168406
PubMed_21979375_A2Up1.2931934695
GSE35957Down-0.5528520430
GSE36640Up0.6109082096
GSE54402Up0.6207412583
GSE9593Down-0.2945462237
GSE43922Up0.8466805283
GSE24585Up0.3101500422
GSE37065Up0.3984516139
GSE28863_A1Up0.1095109635
GSE28863_A2Up0.1973508898
GSE28863_A3Down-0.3853953671
GSE28863_A4Down-0.0496092046
GSE48662Up0.1109864805

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Decanoic AcidDB03600 EXPT01213 | DB03838
PirfenidoneDB04951 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT005919Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20945401
hsa-miR-103a-3pMIMAT0000101MIRT027060SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031785SequencingFunctional MTI (Weak)20371350
hsa-miR-615-3pMIMAT0003283MIRT039979CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042240CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.