HCSGD entry for PEBP1
1. General information
| Official gene symbol | PEBP1 |
|---|---|
| Entrez ID | 5037 |
| Gene full name | phosphatidylethanolamine binding protein 1 |
| Other gene symbols | HCNP HCNPpp PBP PEBP PEBP-1 RKIP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0008429 | Phosphatidylethanolamine binding | TAS | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6700405570 | 0.2202962387 | 0.9999902473 | 0.9034617170 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5166549867 |
| GSE13712_SHEAR | Down | -0.1770263683 |
| GSE13712_STATIC | Down | -0.0068430749 |
| GSE19018 | Up | 0.1833619417 |
| GSE19899_A1 | Down | -0.7862534377 |
| GSE19899_A2 | Up | 0.1613574126 |
| PubMed_21979375_A1 | Down | -0.5246533803 |
| PubMed_21979375_A2 | Down | -0.4340512337 |
| GSE35957 | Down | -0.0384149642 |
| GSE36640 | Up | 0.0934803757 |
| GSE54402 | Down | -0.0491752976 |
| GSE9593 | Up | 0.3618589855 |
| GSE43922 | Down | -0.1506805607 |
| GSE24585 | Down | -0.3498842943 |
| GSE37065 | Down | -0.1078543902 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.3006431751 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | MIRT007008 | Luciferase reporter assay | Functional MTI | 22809510 |
| hsa-miR-375 | MIMAT0000728 | MIRT019828 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020686 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046731 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049454 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23814485 | A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation |
| 23814485 | Through several molecular biologic analyses, we found that RKIP, an inhibitor of Raf kinase, is responsible for p53-mediated ERK suppression and senescence |
| 23814485 | Overexpression of RKIP can induce cellular senescence in several types of cell lines, including p53-deficient cells, whereas the elimination of RKIP by siRNA or forced expression of ERK blocks p53-mediated cellular senescence |
| 23814485 | These results suggested that RKIP is an essential protein for cellular senescence |
| 23814485 | Moreover, modification of the p53 serine 46 residue was critical for RKIP induction and ERK suppression as well as cellular senescence |
| 23814485 | These results indicated that RKIP is a novel p53 target gene that is responsible for p53-mediated cellular senescence and tumor suppressor protein expression |
| 22833545 | Secretome analysis of ionizing radiation-induced senescent cancer cells reveals that secreted RKIP plays a critical role in neighboring cell migration |
| 22833545 | Comparative proteomics analysis revealed 24 differentially secreted protein spots including Raf kinase inhibitor protein (RKIP), alpha-Enolase, AKAP9, and MARK4, and the findings were confirmed by Western blot analysis of IR-induced senescent cancer cells |
| 22833545 | We found that RKIP was secreted via the classical pathway, and the transfection of small interfering RNA against RKIP suppressed CM-induced migration in MCF7 cells |
| 22833545 | Treatment with recombinant human RKIP increased the migratory activity of MCF7 cells |
| 22833545 | Taken together, our results demonstrate that the senescence-associated secretory protein RKIP could be the principal target to prevent the potential effects of the secretome from IR-induced senescent tumor cells on neighboring cell migration |
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