HCSGD entry for P2RY1

1. General information

Official gene symbolP2RY1
Entrez ID5028
Gene full namepurinergic receptor P2Y, G-protein coupled, 1
Other gene symbolsP2Y1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationISSbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneISS TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationISSbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010469Regulation of receptor activityIEAbiological_process
GO:0010700Negative regulation of norepinephrine secretionIEAbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0019233Sensory perception of painIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionISSbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030425DendriteISScellular_component
GO:0031686A1 adenosine receptor bindingIEAmolecular_function
GO:0032962Positive regulation of inositol trisphosphate biosynthetic processIEAbiological_process
GO:0042312Regulation of vasodilationIEAbiological_process
GO:0042755Eating behaviorIEAbiological_process
GO:0043270Positive regulation of ion transportIEAbiological_process
GO:0043531ADP bindingIEAmolecular_function
GO:0044297Cell bodyISScellular_component
GO:0045028G-protein coupled purinergic nucleotide receptor activityISSmolecular_function
GO:0045031ATP-activated nucleotide receptor activityIEAmolecular_function
GO:0045032ADP-activated nucleotide receptor activityIEAmolecular_function
GO:0045211Postsynaptic membraneISScellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046887Positive regulation of hormone secretionIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0051100Negative regulation of bindingIEAbiological_process
GO:0060406Positive regulation of penile erectionIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0070848Response to growth factorIEAbiological_process
GO:0072659Protein localization to plasma membraneISSbiological_process
GO:0090075Relaxation of muscleIEAbiological_process
GO:0097110Scaffold protein bindingISSmolecular_function
GO:0097481Neuronal postsynaptic densityISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78782943660.16605548420.99999024730.7890858278

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2010789583
GSE13712_SHEARDown-0.2291001910
GSE13712_STATICDown-0.2645788065
GSE19018Down-0.1039744243
GSE19899_A1Up0.1497238959
GSE19899_A2Down-0.0976433440
PubMed_21979375_A1Up0.1543865965
PubMed_21979375_A2Up0.2288388884
GSE35957Up0.1990800429
GSE36640Down-0.0085615882
GSE54402Down-2.7497568539
GSE9593Up0.1858332261
GSE43922Up0.0231708843
GSE24585Down-0.2343423609
GSE37065Down-0.1020903978
GSE28863_A1Down-0.0136000517
GSE28863_A2Up0.0775886617
GSE28863_A3Up0.1684871596
GSE28863_A4Up0.1187469062
GSE48662Down-0.0545610363

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17982416Agonists of P2Y1 (ADP) and P2Y2/P2Y4 (ATP, UTP) receptors at 10 microM or 100 microM concentrations were added to the bathing medium
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