HCSGD entry for OXTR

1. General information

Official gene symbolOXTR
Entrez ID5021
Gene full nameoxytocin receptor
Other gene symbolsOT-R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001967Suckling behaviorIEAbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0004990Oxytocin receptor activityIEAmolecular_function
GO:0005000Vasopressin receptor activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005902MicrovillusIEAcellular_component
GO:0005913Cell-cell adherens junctionIEAcellular_component
GO:0006936Muscle contractionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007595LactationTASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0010701Positive regulation of norepinephrine secretionIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0017046Peptide hormone bindingIEAmolecular_function
GO:0021537Telencephalon developmentIEAbiological_process
GO:0030431SleepIEAbiological_process
GO:0032230Positive regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0034059Response to anoxiaIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0035176Social behaviorIEAbiological_process
GO:0042220Response to cocaineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042711Maternal behaviorIEAbiological_process
GO:0042713Sperm ejaculationIEAbiological_process
GO:0042755Eating behaviorIEAbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045777Positive regulation of blood pressureIEAbiological_process
GO:0048565Digestive tract developmentIEAbiological_process
GO:0051965Positive regulation of synapse assemblyIEAbiological_process
GO:0051968Positive regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0060137Maternal process involved in parturitionIEAbiological_process
GO:0060206Estrous cycle phaseIEAbiological_process
GO:0060406Positive regulation of penile erectionIEAbiological_process
GO:0060455Negative regulation of gastric acid secretionIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0070474Positive regulation of uterine smooth muscle contractionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48670884080.00000646250.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-4.2017040823
GSE13712_SHEARUp0.1538776224
GSE13712_STATICUp0.0539781904
GSE19018Up2.0574187420
GSE19899_A1Down-0.2918354225
GSE19899_A2Down-6.2978815862
PubMed_21979375_A1Down-5.6857216509
PubMed_21979375_A2Down-6.8234660086
GSE35957Up3.0315059257
GSE36640Down-1.1883152461
GSE54402Down-2.3096311341
GSE9593Down-0.1633425361
GSE43922Down-2.3871762020
GSE24585Down-0.3477798456
GSE37065Down-0.3850791593
GSE28863_A1Down-1.9048055434
GSE28863_A2Down-1.4197688818
GSE28863_A3Down-1.2860644115
GSE28863_A4Down-0.2890612727
GSE48662Down-0.4359962351

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

OxytocinDB00107 BTD00016 | BIOD00016
CarbetocinDB01282 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023713MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26903639The oxytocin receptor gene (OXTR) polymorphism rs53576, which has figured prominently in investigations of social cognition and psychological resources, and the estrogen receptor beta gene (ESR2) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative effect of impatience on cellular aging in females
12135889Telomerase-expressing cells contained mRNA for alpha smooth muscle actin, smoothelin, oxytocin receptor, and estrogen receptor alpha, but the estrogen receptor beta receptor was lost
12135889Immunoblotting analysis identified the expression of calponin, caldesmon, alpha smooth muscle actin, and oxytocin receptor
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