HCSGD entry for OTX2

1. General information

Official gene symbolOTX2
Entrez ID5015
Gene full nameorthodenticle homeobox 2
Other gene symbolsCPHD6 MCOPS5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001708Cell fate specificationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006461Protein complex assemblyIDAbiological_process
GO:0007411Axon guidanceIDAbiological_process
GO:0007492Endoderm developmentIEAbiological_process
GO:0008190Eukaryotic initiation factor 4E bindingTASmolecular_function
GO:0008589Regulation of smoothened signaling pathwayTASbiological_process
GO:0009953Dorsal/ventral pattern formationIEAbiological_process
GO:0022037Metencephalon developmentIEAbiological_process
GO:0030426Growth coneIDAcellular_component
GO:0030900Forebrain developmentTASbiological_process
GO:0030901Midbrain developmentIEA TASbiological_process
GO:0032525Somite rostral/caudal axis specificationIEAbiological_process
GO:0040019Positive regulation of embryonic developmentISSbiological_process
GO:0040036Regulation of fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0042706Eye photoreceptor cell fate commitmentIEAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048852Diencephalon morphogenesisIEAbiological_process
GO:0090009Primitive streak formationIEA ISSbiological_process
GO:2000543Positive regulation of gastrulationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61887506170.88208433950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0126490639
GSE13712_SHEARUp0.0683369755
GSE13712_STATICDown-0.0031714161
GSE19018Down-0.0930980630
GSE19899_A1Up0.0367306198
GSE19899_A2Up0.1962646017
PubMed_21979375_A1Up0.0839074127
PubMed_21979375_A2Down-0.1331301630
GSE35957Up0.1784552224
GSE36640Down-0.0625373407
GSE54402Down-0.0372110786
GSE9593Up0.1303969803
GSE43922Up0.0924473789
GSE24585Up0.1274028955
GSE37065Up0.0151346047
GSE28863_A1Down-0.1284233771
GSE28863_A2Up0.1708111452
GSE28863_A3Up0.1065066648
GSE28863_A4Up0.0813095641
GSE48662Down-0.1045433045

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT025137MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21047732Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines
21047732The transcription factor orthodenticle homeobox 2 (OTX2) has been implicated in the pathogenesis of medulloblastoma, as it is often highly expressed and sometimes amplified in these tumors
21047732Little is known of the downstream pathways regulated by OTX2
21047732We therefore generated MED8A and DAOY medulloblastoma cell lines with doxycycline-inducible OTX2 expression
21047732In both cell lines, OTX2 inhibited proliferation and induced a senescence-like phenotype with senescence-associated beta-galactosidase activity
21047732Expression profiles of time series after OTX2 induction in MED8A showed early upregulation of cell cycle genes related to the G(2)-M phase, such as AURKA, CDC25C, and CCNG2
21047732ChIP-on-chip analyses of OTX2 binding to promoter regions in MED8A and DAOY showed a strong enrichment for binding to the G(2)-M genes, suggesting a direct activation
21047732Their mRNA expression correlated with OTX2 expression in primary tumors, underscoring the in vivo relevance of this regulation
21047732OTX2 induction activated the P53 pathway in MED8A, but not in DAOY, which carries a mutated P53 gene
21047732In DAOY cells, senescence-associated secretory factors, such as interleukin-6 and insulin-like growth factor binding protein 7, were strongly upregulated after OTX2 induction
21047732We hypothesize that the imbalance in cell cycle stimulation by OTX2 leads to cellular senescence either by activating the P53 pathway or through the induction of secretory factors
21047732Our data indicate that OTX2 directly induces a series of cell cycle genes but requires cooperating genes for an oncogenic acceleration of the cell cycle
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