HCSGD entry for ACO2

1. General information

Official gene symbolACO2
Entrez ID50
Gene full nameaconitase 2, mitochondrial
Other gene symbolsACONM ICRD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003994Aconitate hydratase activityIEAmolecular_function
GO:0005506Iron ion bindingIDAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006091Generation of precursor metabolites and energyTASbiological_process
GO:0006099Tricarboxylic acid cycleIDA IEA TASbiological_process
GO:0006101Citrate metabolic processIDAbiological_process
GO:0006102Isocitrate metabolic processIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:00515383 iron, 4 sulfur cluster bindingIEAmolecular_function
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26143815580.90105509290.95485524421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3909277949
GSE13712_SHEARDown-0.2079158864
GSE13712_STATICUp0.0489085666
GSE19018Down-0.0437390181
GSE19899_A1Down-0.0017032625
GSE19899_A2Up0.1729697884
PubMed_21979375_A1Up0.5529571821
PubMed_21979375_A2Up0.4216594161
GSE35957Down-0.1519836969
GSE36640Up0.1032925408
GSE54402Up0.1439166572
GSE9593Down-0.1305101563
GSE43922Down-0.0510678782
GSE24585Up0.4131675231
GSE37065Down-0.1184222494
GSE28863_A1Up0.1646069002
GSE28863_A2Up0.0373159349
GSE28863_A3Down-0.1105380270
GSE28863_A4Up0.0336979992
GSE48662Up0.1668641876

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Isocitric AcidDB01727 EXPT01834
4-Hydroxy-Aconitate IonDB03964 EXPT00582
Alpha-Methylisocitric AcidDB04072 EXPT02174
Aconitate IonDB04351 EXPT03104
Tricarballylic AcidDB04562 EXPT03105

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.