HCSGD entry for ORC2
1. General information
| Official gene symbol | ORC2 |
|---|---|
| Entrez ID | 4999 |
| Gene full name | origin recognition complex, subunit 2 |
| Other gene symbols | ORC2L |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000792 | Heterochromatin | IEA | cellular_component |
| GO:0000808 | Origin recognition complex | IDA | cellular_component |
| GO:0000939 | Condensed chromosome inner kinetochore | IEA | cellular_component |
| GO:0003688 | DNA replication origin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005664 | Nuclear origin of replication recognition complex | IDA IEA | cellular_component |
| GO:0006260 | DNA replication | IEA TAS | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9947353596 | 0.0116307131 | 0.9999902473 | 0.2129326147 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0740646698 |
| GSE13712_SHEAR | Down | -0.0570966305 |
| GSE13712_STATIC | Down | -0.1805102546 |
| GSE19018 | Down | -0.1683782857 |
| GSE19899_A1 | Down | -0.2918800306 |
| GSE19899_A2 | Down | -0.7608748250 |
| PubMed_21979375_A1 | Up | 0.0535006293 |
| PubMed_21979375_A2 | Down | -0.7464172335 |
| GSE35957 | Down | -0.5589656242 |
| GSE36640 | Down | -0.8532069710 |
| GSE54402 | Down | -0.3138586117 |
| GSE9593 | Down | -0.5336615625 |
| GSE43922 | Down | -0.3631576913 |
| GSE24585 | Down | -0.1092815305 |
| GSE37065 | Up | 0.0994144758 |
| GSE28863_A1 | Down | -0.1620005575 |
| GSE28863_A2 | Down | -0.0364002438 |
| GSE28863_A3 | Down | -0.6889571807 |
| GSE28863_A4 | Down | -0.2611303560 |
| GSE48662 | Down | -0.1543494167 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023388 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037366 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041002 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048408 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
