HCSGD entry for OPHN1

1. General information

Official gene symbolOPHN1
Entrez ID4983
Gene full nameoligophrenin 1
Other gene symbolsARHGAP41 MRX60 OPN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIEAmolecular_function
GO:0005096GTPase activator activityIEAmolecular_function
GO:0005100Rho GTPase activator activityIEAmolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006930Substrate-dependent cell migration, cell extensionTASbiological_process
GO:0007165Signal transductionIEA TASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0015629Actin cytoskeletonIEAcellular_component
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030100Regulation of endocytosisIEAbiological_process
GO:0035255Ionotropic glutamate receptor bindingIEAmolecular_function
GO:0043195Terminal boutonIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0048488Synaptic vesicle endocytosisIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051966Regulation of synaptic transmission, glutamatergicIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46162574750.28036996310.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3263861590
GSE13712_SHEARDown-0.5089392412
GSE13712_STATICDown-0.2494611364
GSE19018Up0.0808176234
GSE19899_A1Down-0.1220930068
GSE19899_A2Down-0.0281118199
PubMed_21979375_A1Down-0.4632278682
PubMed_21979375_A2Up0.3196160034
GSE35957Up0.3703622243
GSE36640Down-0.0832809958
GSE54402Up0.0741634148
GSE9593Down-0.5379610338
GSE43922Down-0.6333527895
GSE24585Up0.0991669795
GSE37065Up0.1529159067
GSE28863_A1Up0.1280327002
GSE28863_A2Up0.2412299230
GSE28863_A3Up0.0434652475
GSE28863_A4Down-0.0157886155
GSE48662Down-0.0074622651

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.