HCSGD entry for TNFRSF11B

1. General information

Official gene symbolTNFRSF11B
Entrez ID4982
Gene full nametumor necrosis factor receptor superfamily, member 11b
Other gene symbolsOCIF OPG TR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentTASbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0005125Cytokine activityTASmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0032026Response to magnesium ionIEAbiological_process
GO:0042489Negative regulation of odontogenesis of dentin-containing toothIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0045779Negative regulation of bone resorptionIEAbiological_process
GO:0046685Response to arsenic-containing substanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03584699670.05216333350.43122888480.4296074781

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-2.2435573922
GSE13712_SHEARDown-0.1101842016
GSE13712_STATICUp0.0191999664
GSE19018Down-1.0213059314
GSE19899_A1Down-0.4517236487
GSE19899_A2Down-0.0467784709
PubMed_21979375_A1Down-0.6118915292
PubMed_21979375_A2Up0.1591511122
GSE35957Up1.6449970423
GSE36640Up2.2715834557
GSE54402Up0.2363439206
GSE9593Up1.0430788084
GSE43922Down-0.0389818577
GSE24585Down-0.0680445997
GSE37065Up0.4116475550
GSE28863_A1Down-0.1225003958
GSE28863_A2Up0.0434055933
GSE28863_A3Up0.0360050276
GSE28863_A4Up0.5074764906
GSE48662Down-0.0485942280

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT023202MicroarrayFunctional MTI (Weak)18668037
hsa-miR-21-5pMIMAT0000076MIRT031067MicroarrayFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25220188Six genes independently correlated with either age (IL-6, TNFRSF-11B, IGFBP-3, SAA4, and COPG), prognosis (IL-6, SAA4), or the grade of the glioma (IL-6, IL-8, ICAM-1, IGFBP-3, and COPG)
19449178Passage-affected competitive regulation of osteoprotegerin synthesis and the receptor activator of nuclear factor-kappaB ligand mRNA expression in normal human osteoblasts stimulated by the application of cyclic tensile strain
10958924Effects of ageing on proliferative ability, and the expressions of secreted protein, acidic and rich in cysteine (SPARC) and osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human periodontal ligament cells
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