HCSGD entry for ATP5A1
1. General information
| Official gene symbol | ATP5A1 |
|---|---|
| Entrez ID | 498 |
| Gene full name | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle |
| Other gene symbols | ATP5A ATP5AL2 ATPM MC5DN4 MOM2 OMR ORM hATP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001937 | Negative regulation of endothelial cell proliferation | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA ISS | molecular_function |
| GO:0005739 | Mitochondrion | NAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IDA IEA | cellular_component |
| GO:0005753 | Mitochondrial proton-transporting ATP synthase complex | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA ISS | biological_process |
| GO:0006629 | Lipid metabolic process | IEA ISS | biological_process |
| GO:0006754 | ATP biosynthetic process | IC NAS | biological_process |
| GO:0008180 | COP9 signalosome | IDA | cellular_component |
| GO:0009790 | Embryo development | IEA ISS | biological_process |
| GO:0015986 | ATP synthesis coupled proton transport | IEA | biological_process |
| GO:0015991 | ATP hydrolysis coupled proton transport | IEA | biological_process |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0022857 | Transmembrane transporter activity | IC | molecular_function |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0042288 | MHC class I protein binding | IDA | molecular_function |
| GO:0042776 | Mitochondrial ATP synthesis coupled proton transport | IC TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045261 | Proton-transporting ATP synthase complex, catalytic core F(1) | IEA | cellular_component |
| GO:0046933 | Proton-transporting ATP synthase activity, rotational mechanism | IEA ISS | molecular_function |
| GO:0046961 | Proton-transporting ATPase activity, rotational mechanism | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8588458645 | 0.3404469359 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0258681842 |
| GSE13712_SHEAR | Down | -0.0960166458 |
| GSE13712_STATIC | Up | 0.0905748792 |
| GSE19018 | Up | 0.0476845603 |
| GSE19899_A1 | Down | -0.0138775199 |
| GSE19899_A2 | Down | -0.0056360154 |
| PubMed_21979375_A1 | Up | 0.0950151293 |
| PubMed_21979375_A2 | Down | -0.0266068994 |
| GSE35957 | Up | 0.1015767264 |
| GSE36640 | Down | -0.0370311905 |
| GSE54402 | Up | 0.0142146956 |
| GSE9593 | Down | -0.1074937308 |
| GSE43922 | Down | -0.1541427412 |
| GSE24585 | Down | -0.1975897168 |
| GSE37065 | Down | -0.2945552137 |
| GSE28863_A1 | Down | -0.1120556192 |
| GSE28863_A2 | Down | -0.1177556838 |
| GSE28863_A3 | Up | 0.3861674860 |
| GSE28863_A4 | Up | 0.2422518299 |
| GSE48662 | Down | -0.4706410934 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Quercetin | DB04216 | EXPT02732 |
| 1-ACETYL-2-CARBOXYPIPERIDINE | DB07384 | - |
| AUROVERTIN B | DB07394 | - |
| PICEATANNOL | DB08399 | - |
| N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE | DB08629 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035973 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036319 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036975 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040790 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045621 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046330 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048470 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049517 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050196 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050432 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051171 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
