HCSGD entry for OPA1
1. General information
| Official gene symbol | OPA1 |
|---|---|
| Entrez ID | 4976 |
| Gene full name | optic atrophy 1 (autosomal dominant) |
| Other gene symbols | MGM1 NPG NTG largeG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000266 | Mitochondrial fission | TAS | biological_process |
| GO:0000287 | Magnesium ion binding | NAS | molecular_function |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0003924 | GTPase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA NAS | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | ISS | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007005 | Mitochondrion organization | IMP NAS | biological_process |
| GO:0007007 | Inner mitochondrial membrane organization | IDA | biological_process |
| GO:0007601 | Visual perception | IMP | biological_process |
| GO:0008053 | Mitochondrial fusion | IDA IEA IMP TAS | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019896 | Axon transport of mitochondrion | TAS | biological_process |
| GO:0030061 | Mitochondrial crista | IDA | cellular_component |
| GO:0030425 | Dendrite | ISS | cellular_component |
| GO:0090201 | Negative regulation of release of cytochrome c from mitochondria | IMP | biological_process |
| GO:0090398 | Cellular senescence | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9822117055 | 0.0240107975 | 0.9999902473 | 0.2988123877 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1503690601 |
| GSE13712_SHEAR | Down | -0.1935811195 |
| GSE13712_STATIC | Up | 0.2805251849 |
| GSE19018 | Down | -0.1435751125 |
| GSE19899_A1 | Down | -0.4656270279 |
| GSE19899_A2 | Down | -0.5704834439 |
| PubMed_21979375_A1 | Down | -0.9464917811 |
| PubMed_21979375_A2 | Down | -0.5428999268 |
| GSE35957 | Up | 0.0934961737 |
| GSE36640 | Down | -0.3187702283 |
| GSE54402 | Down | -0.2368451001 |
| GSE9593 | Down | -0.0507220203 |
| GSE43922 | Down | -0.2607800717 |
| GSE24585 | Down | -0.2076053387 |
| GSE37065 | Down | -0.0777497193 |
| GSE28863_A1 | Up | 0.1289037913 |
| GSE28863_A2 | Up | 0.4102033328 |
| GSE28863_A3 | Down | -0.5898676023 |
| GSE28863_A4 | Down | -0.3229130452 |
| GSE48662 | Down | -0.0441807465 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019759 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024444 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026273 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-320a | MIMAT0000510 | MIRT044835 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047347 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 28018212 | These changes in morphology were related to slightly levels increases in mitochondrial fusion proteins, Mitofusion 1 (MFN1), and Dynamin-related GTPase (OPA1) |
| 24056969 | Mitochondrial fragmentation was induced by knockdown of mitochondrial fusion proteins (OPA1 or Mitofusins) by small-interfering RNA transfection |
| 17545159 | Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence |
| 17545159 | Moreover, depletion of both hFis1 and OPA1, a critical component of mitochondrial fusion, resulted in extensive mitochondrial fragmentation and markedly rescued cells from senescence-associated phenotypic changes |
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