HCSGD entry for OLR1
1. General information
| Official gene symbol | OLR1 |
|---|---|
| Entrez ID | 4973 |
| Gene full name | oxidized low density lipoprotein (lectin-like) receptor 1 |
| Other gene symbols | CLEC8A LOX1 LOXIN SCARE1 SLOX1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005041 | Low-density lipoprotein receptor activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007159 | Leukocyte cell-cell adhesion | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008015 | Blood circulation | TAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
| GO:0042157 | Lipoprotein metabolic process | IEA | biological_process |
| GO:0042542 | Response to hydrogen peroxide | IEA | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7227980434 | 0.0001720337 | 0.9999902473 | 0.0242144385 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0789096051 |
| GSE13712_SHEAR | Down | -0.1606079189 |
| GSE13712_STATIC | Down | -0.1116554314 |
| GSE19018 | Down | -1.0362794469 |
| GSE19899_A1 | Down | -0.6177408741 |
| GSE19899_A2 | Down | -3.1059988731 |
| PubMed_21979375_A1 | Down | -3.3903247876 |
| PubMed_21979375_A2 | Down | -3.5734403151 |
| GSE35957 | Down | -0.2142020831 |
| GSE36640 | Up | 5.3217406520 |
| GSE54402 | Down | -1.3216545021 |
| GSE9593 | Up | 0.3098171091 |
| GSE43922 | Down | -2.1184226950 |
| GSE24585 | Down | -0.1605680776 |
| GSE37065 | Down | -0.0182477174 |
| GSE28863_A1 | Down | -0.6342125721 |
| GSE28863_A2 | Down | -2.0588255960 |
| GSE28863_A3 | Down | -0.6786570466 |
| GSE28863_A4 | Down | -0.0375483062 |
| GSE48662 | Down | -0.0185384215 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020773 | Western blot | Functional MTI | 21030878 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027749 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031012 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25388834 | Ox-LDL receptor-1 (LOX-1) plays a central role in ox-LDL-mediated atherosclerosis via endothelial nitric oxide synthase (eNOS) uncoupling and nitric oxide reduction |
| 25388834 | Therefore, we tested the hypothesis that ciglitazone, the PPARgamma agonist, protected endothelial cells against ox-LDL through regulating eNOS activity and LOX-1 signalling |
| 25388834 | Ox-LDL-induced suppression of eNOS and nitric oxide synthesis were largely prevented by silencing LOX-1 |
| 22814745 | Strikingly, aortic explants from mice lacking lectin-like oxidized low-density lipoprotein receptor-1, a pattern-recognition receptor, were essentially unable to respond to UCMVs, whereas simultaneously treated explants from wild-type mice responded robustly by increasing monocyte recruitment |
| 21698300 | Potential involvement of LOX-1 in functional consequences of endothelial senescence |
| 21698300 | The analysis of a scavenger receptor LOX-1, a key molecule implicated in atherogenesis, revealed a significant decline of its message (mRNA) and protein content in senescent endothelial cells (-33%) and in aortas of 50 wk (vs |
| 21698300 | These changes in senescent endothelial cells are suggestive of aberrant responses to physiological stimuli resulting in a less permissive environment for tissue remodeling and progression of diseases requiring angiogenesis and cell adhesion in elderly, possibly, mediated by LOX-1 |
| 15236625 | Oxidized LDL-induced EPC senescence was significantly inhibited by pretreatment with either lectin-like ox-LDL receptor-1 (LOX-1) antibody (Ab) or atorvastatin (P < 0 |
| 15236625 | Oxidized LDL significantly diminished telomerase activity to approximately 50%, an effect that was significantly abolished by pretreatment with either LOX-1 Ab or atorvastatin (P < 0 |
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