HCSGD entry for ODC1

1. General information

Official gene symbolODC1
Entrez ID4953
Gene full nameornithine decarboxylase 1
Other gene symbolsODC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIEAbiological_process
GO:0004586Ornithine decarboxylase activityIEA TASmolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006595Polyamine metabolic processTASbiological_process
GO:0006596Polyamine biosynthetic processIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009615Response to virusIEPbiological_process
GO:0033387Putrescine biosynthetic process from ornithineIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02663377530.04089280800.38030904660.3810051681

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.3888230707
GSE13712_SHEARDown-0.0249160336
GSE13712_STATICUp0.0994325456
GSE19018Down-0.9600345852
GSE19899_A1Up0.8675210472
GSE19899_A2Up0.5749034949
PubMed_21979375_A1Up1.2572390467
PubMed_21979375_A2Up0.3295439134
GSE35957Down-0.7669894329
GSE36640Down-0.4331495680
GSE54402Up1.5936416924
GSE9593Down-0.6471538776
GSE43922Up0.5155190814
GSE24585Down-0.7138120431
GSE37065Down-0.3156890229
GSE28863_A1Down-0.0691353600
GSE28863_A2Down-0.6711957857
GSE28863_A3Down-0.6087955713
GSE28863_A4Up0.0941964333
GSE48662Down-0.4433979969

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SpermineDB00127 NUTR00055 | EXPT02947 | DB02564
PutrescineDB01917 EXPT02702
Pyridoxine-5'-PhosphateDB02209 EXPT02710
N-Pyridoxyl-Glycine-5-MonophosphateDB02824 EXPT02606
Alpha-DifluoromethylornithineDB03856 EXPT01229
N'-Pyridoxyl-Lysine-5'-MonophosphateDB04083 EXPT02040
GeneticinDB04263 EXPT01586
EflornithineDB06243 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004127MicroarrayFunctional MTI (Weak)16822819
hsa-miR-193b-3pMIMAT0002819MIRT041549CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042942CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048600CLASHFunctional MTI (Weak)23622248
hsa-miR-15a-5pMIMAT0000068MIRT051317CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

2632284Aging of IMR-90 human diploid fibroblasts in culture is accompanied by specific changes of polyamine metabolism including: (a) a fivefold decrease of serum-induced activity of ornithine decarboxylase (ODC1 EC 4
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