HCSGD entry for OAS1

1. General information

Official gene symbolOAS1
Entrez ID4938
Gene full name2'-5'-oligoadenylate synthetase 1, 40/46kDa
Other gene symbolsIFI-4 OIAS OIASI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00017302'-5'-oligoadenylate synthetase activityIDAmolecular_function
GO:0003725Double-stranded RNA bindingIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEA TASmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006164Purine nucleotide biosynthetic processIDAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0009615Response to virusIDAbiological_process
GO:0016740Transferase activityIEAmolecular_function
GO:0016779Nucleotidyltransferase activityIEAmolecular_function
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0035457Cellular response to interferon-alphaIDAbiological_process
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051259Protein oligomerizationIDAbiological_process
GO:0051607Defense response to virusIDA IEAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060700Regulation of ribonuclease activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00315772960.44351243110.15143132971.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1385140987
GSE13712_SHEARUp1.9326084296
GSE13712_STATICUp2.3224518130
GSE19018Up0.1331833106
GSE19899_A1Up0.0830592201
GSE19899_A2Up0.1601386612
PubMed_21979375_A1Up0.0643873977
PubMed_21979375_A2Up0.1131054832
GSE35957Down-4.5886925168
GSE36640Up1.0241126316
GSE54402Down-0.0682050884
GSE9593Down-0.2733323927
GSE43922Up0.2876662103
GSE24585Up0.8522933239
GSE37065Up1.9997250923
GSE28863_A1Down-0.3795953387
GSE28863_A2Up2.4240054189
GSE28863_A3Down-0.0248652557
GSE28863_A4Down-0.0116298932
GSE48662Up0.0456853632

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Cysteine-S-AcetamideDB02987 EXPT03271

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018171MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.