HCSGD entry for ROR2

1. General information

Official gene symbolROR2
Entrez ID4920
Gene full namereceptor tyrosine kinase-like orphan receptor 2
Other gene symbolsBDB BDB1 NTRKR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001502Cartilage condensationIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005109Frizzled bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEAbiological_process
GO:0007223Wnt signaling pathway, calcium modulating pathwayIEAbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0017147Wnt-protein bindingIPImolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030538Embryonic genitalia morphogenesisIEAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0060071Wnt signaling pathway, planar cell polarity pathwayIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93301977510.02982205080.99999024730.3263840748

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2771585806
GSE13712_SHEARUp0.0276218072
GSE13712_STATICDown-0.0386695281
GSE19018Down-0.5289894322
GSE19899_A1Down-0.0324808377
GSE19899_A2Down-0.7519451437
PubMed_21979375_A1Down-0.5788074865
PubMed_21979375_A2Down-0.3937309843
GSE35957Up0.0601158901
GSE36640Down-1.2696166746
GSE54402Down-1.1520948733
GSE9593Down-0.0315666763
GSE43922Down-0.0790287194
GSE24585Down-0.0766914146
GSE37065Down-0.1251127891
GSE28863_A1Up0.3275826112
GSE28863_A2Up0.5611448780
GSE28863_A3Up0.0752199680
GSE28863_A4Up0.0863391441
GSE48662Up0.0600205489

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016864MicroarrayFunctional MTI (Weak)18185580
hsa-let-7f-5pMIMAT0000067MIRT051386CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.