HCSGD entry for NTRK2

1. General information

Official gene symbolNTRK2
Entrez ID4915
Gene full nameneurotrophic tyrosine kinase, receptor, type 2
Other gene symbolsGP145-TrkB TRKB trk-B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001570VasculogenesisIEAbiological_process
GO:0001764Neuron migrationISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolIEAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0007190Activation of adenylate cyclase activityTASbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007612LearningISSbiological_process
GO:0007616Long-term memoryIEAbiological_process
GO:0007631Feeding behaviorIEAbiological_process
GO:0008284Positive regulation of cell proliferationISSbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010008Endosome membraneIEAcellular_component
GO:0010628Positive regulation of gene expressionISSbiological_process
GO:0010976Positive regulation of neuron projection developmentISSbiological_process
GO:0010996Response to auditory stimulusIEAbiological_process
GO:0014047Glutamate secretionIEAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingISSbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIMPbiological_process
GO:0021954Central nervous system neuron developmentISSbiological_process
GO:0021987Cerebral cortex developmentISSbiological_process
GO:0030182Neuron differentiationISSbiological_process
GO:0030426Growth coneIEAcellular_component
GO:0031547Brain-derived neurotrophic factor receptor signaling pathwayIMPbiological_process
GO:0032314Regulation of Rac GTPase activityISSbiological_process
GO:0035584Calcium-mediated signaling using intracellular calcium sourceIEAbiological_process
GO:0042490Mechanoreceptor differentiationIEAbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043121Neurotrophin bindingIDA ISSmolecular_function
GO:0043195Terminal boutonIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0043410Positive regulation of MAPK cascadeISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processISSbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0046548Retinal rod cell developmentIEAbiological_process
GO:0046777Protein autophosphorylationISSbiological_process
GO:0046875Ephrin receptor bindingIEAmolecular_function
GO:0046928Regulation of neurotransmitter secretionIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048403Brain-derived neurotrophic factor bindingISSmolecular_function
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0048786Presynaptic active zoneIEAcellular_component
GO:0048935Peripheral nervous system neuron developmentIEAbiological_process
GO:0050772Positive regulation of axonogenesisISSbiological_process
GO:0050773Regulation of dendrite developmentIEAbiological_process
GO:0051896Regulation of protein kinase B signalingIEAbiological_process
GO:0051968Positive regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0060076Excitatory synapseIEAcellular_component
GO:0060175Brain-derived neurotrophic factor-activated receptor activityIMPmolecular_function
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:2000811Negative regulation of anoikisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10099392120.90574598230.66238274921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0272396645
GSE13712_SHEARDown-0.0507808710
GSE13712_STATICDown-0.0335883949
GSE19018Up0.1121466282
GSE19899_A1Up0.0879037851
GSE19899_A2Up0.1160285779
PubMed_21979375_A1Up0.0169216325
PubMed_21979375_A2Down-0.0410112233
GSE35957Up0.0281190819
GSE36640Up0.0135723372
GSE54402Down-0.0030184391
GSE9593Down-0.2310406194
GSE43922Up0.0614185089
GSE24585Up0.5982317546
GSE37065Up0.2371323113
GSE28863_A1Down-0.0231009062
GSE28863_A2Up0.1623557918
GSE28863_A3Up0.6116472660
GSE28863_A4Up0.2455634889
GSE48662Up0.4621279264

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT006434Immunoblot//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21501518
hsa-miR-335-5pMIMAT0000765MIRT019226MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.