HCSGD entry for NTRK1
1. General information
| Official gene symbol | NTRK1 |
|---|---|
| Entrez ID | 4914 |
| Gene full name | neurotrophic tyrosine kinase, receptor, type 1 |
| Other gene symbols | MTC TRK TRK1 TRKA Trk-A p140-TrkA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | TAS | biological_process |
| GO:0004714 | Transmembrane receptor protein tyrosine kinase activity | IDA IEA | molecular_function |
| GO:0005030 | Neurotrophin receptor activity | IEA | molecular_function |
| GO:0005166 | Neurotrophin p75 receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005768 | Endosome | TAS | cellular_component |
| GO:0005769 | Early endosome | ISS | cellular_component |
| GO:0005770 | Late endosome | ISS | cellular_component |
| GO:0005886 | Plasma membrane | ISS TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | IEA TAS | biological_process |
| GO:0007190 | Activation of adenylate cyclase activity | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0007611 | Learning or memory | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0009314 | Response to radiation | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0010465 | Nerve growth factor receptor activity | IDA | molecular_function |
| GO:0010623 | Developmental programmed cell death | ISS | biological_process |
| GO:0010976 | Positive regulation of neuron projection development | IDA | biological_process |
| GO:0014823 | Response to activity | IEA | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0021553 | Olfactory nerve development | IEA | biological_process |
| GO:0030183 | B cell differentiation | IEA | biological_process |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0031667 | Response to nutrient levels | IEA | biological_process |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0031902 | Late endosome membrane | IEA | cellular_component |
| GO:0032320 | Positive regulation of Ras GTPase activity | IDA | biological_process |
| GO:0042490 | Mechanoreceptor differentiation | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043068 | Positive regulation of programmed cell death | ISS | biological_process |
| GO:0043121 | Neurotrophin binding | TAS | molecular_function |
| GO:0043234 | Protein complex | ISS | cellular_component |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0043524 | Negative regulation of neuron apoptotic process | ISS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IDA | biological_process |
| GO:0046579 | Positive regulation of Ras protein signal transduction | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0046875 | Ephrin receptor binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | IDA TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0048406 | Nerve growth factor binding | IDA | molecular_function |
| GO:0048485 | Sympathetic nervous system development | ISS | biological_process |
| GO:0048678 | Response to axon injury | IEA | biological_process |
| GO:0050965 | Detection of temperature stimulus involved in sensory perception of pain | IEA | biological_process |
| GO:0050966 | Detection of mechanical stimulus involved in sensory perception of pain | IEA | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0051599 | Response to hydrostatic pressure | IEA | biological_process |
| GO:0051602 | Response to electrical stimulus | IEA | biological_process |
| GO:0051968 | Positive regulation of synaptic transmission, glutamatergic | IEA | biological_process |
| GO:0060009 | Sertoli cell development | IEA | biological_process |
| GO:0060385 | Axonogenesis involved in innervation | ISS | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IDA | biological_process |
| GO:0071316 | Cellular response to nicotine | IEA | biological_process |
| GO:1990090 | Cellular response to nerve growth factor stimulus | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4139995251 | 0.9266318187 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0001960695 |
| GSE13712_SHEAR | Up | 0.0971205361 |
| GSE13712_STATIC | Down | -0.0399767176 |
| GSE19018 | Up | 0.2232515586 |
| GSE19899_A1 | Down | -0.0435517758 |
| GSE19899_A2 | Up | 0.1039464742 |
| PubMed_21979375_A1 | Up | 0.0008025235 |
| PubMed_21979375_A2 | Up | 0.0273767938 |
| GSE35957 | Up | 0.0142743587 |
| GSE36640 | Down | -0.0904848549 |
| GSE54402 | Up | 0.2358930660 |
| GSE9593 | Up | 0.1358384073 |
| GSE43922 | Up | 0.0359414323 |
| GSE24585 | Up | 0.1308001887 |
| GSE37065 | Up | 0.0137355077 |
| GSE28863_A1 | Down | -0.1480411189 |
| GSE28863_A2 | Down | -0.0122982725 |
| GSE28863_A3 | Up | 0.1928688853 |
| GSE28863_A4 | Up | 0.1822617507 |
| GSE48662 | Up | 0.1012181252 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17635673 | Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells |
| 17635673 | The neurotrophin receptor tropomyosin-related kinase A (TrkA) and its ligand nerve growth factor (NGF) are expressed in astrocytomas, and an inverse association of TrkA expression with malignancy grade was described |
| 17635673 | We hypothesized that TrkA expression might confer a growth disadvantage to glioblastoma cells |
| 17635673 | To analyze TrkA function and signaling, we transfected human TrkA cDNA into the human glioblastoma cell line G55 |
| 17635673 | Our findings suggest that TrkA activation in human glioblastomas might be beneficial therapeutically, especially as several of the currently used chemotherapeutics also induce autophagic cell death |
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