HCSGD entry for NTF3

1. General information

Official gene symbolNTF3
Entrez ID4908
Gene full nameneurotrophin 3
Other gene symbolsHDNF NGF-2 NGF2 NT3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIDAbiological_process
GO:0002092Positive regulation of receptor internalizationIDAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005165Neurotrophin receptor bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIDAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007274Neuromuscular synaptic transmissionIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007403Glial cell fate determinationIEAbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007422Peripheral nervous system developmentIEAbiological_process
GO:0008083Growth factor activityIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008544Epidermis developmentIEAbiological_process
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0021675Nerve developmentIEAbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0032148Activation of protein kinase B activityIDAbiological_process
GO:0032856Activation of Ras GTPase activityIDAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0042056Chemoattractant activityIDAmolecular_function
GO:0042490Mechanoreceptor differentiationIEAbiological_process
GO:0042552MyelinationIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045687Positive regulation of glial cell differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048406Nerve growth factor bindingIEAmolecular_function
GO:0048484Enteric nervous system developmentIEAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050804Regulation of synaptic transmissionIEAbiological_process
GO:0050918Positive chemotaxisIDAbiological_process
GO:0050930Induction of positive chemotaxisIDAbiological_process
GO:0051145Smooth muscle cell differentiationIEAbiological_process
GO:2000251Positive regulation of actin cytoskeleton reorganizationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74586160100.00156167320.99999024730.0761200000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3151605218
GSE13712_SHEARDown-0.0325173056
GSE13712_STATICDown-0.1746452156
GSE19018Down-0.4267339115
GSE19899_A1Down-1.3995839171
GSE19899_A2Down-1.3784520047
PubMed_21979375_A1Down-3.8543640105
PubMed_21979375_A2Down-3.7838942848
GSE35957Up1.4246378482
GSE36640Up0.3753056964
GSE54402Down-1.6217315896
GSE9593Up0.1205222039
GSE43922Down-1.6448672700
GSE24585Down-0.1954788453
GSE37065Up0.3591435035
GSE28863_A1Down-0.4360798597
GSE28863_A2Up0.1625268647
GSE28863_A3Down-0.1427683945
GSE28863_A4Up0.1190171858
GSE48662Up0.1866668182

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AV411DB05066 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT007095Luciferase reporter assayFunctional MTI23185507
hsa-miR-335-5pMIMAT0000765MIRT019215MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT0000076NAhsa-miR-2122019057
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.