HCSGD entry for YBX1

1. General information

Official gene symbolYBX1
Entrez ID4904
Gene full nameY box binding protein 1
Other gene symbolsBP-8 CSDA2 CSDB DBPB MDR-NF1 NSEP-1 NSEP1 YB-1 YB1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000398MRNA splicing, via spliceosomeTASbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003677DNA bindingIDA IEA TASmolecular_function
GO:0003690Double-stranded DNA bindingTASmolecular_function
GO:0003697Single-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003723RNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005689U12-type spliceosomal complexIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010494Cytoplasmic stress granuleIDAcellular_component
GO:0030529Ribonucleoprotein complexIDAcellular_component
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0051154Negative regulation of striated muscle cell differentiationIEAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0070934CRD-mediated mRNA stabilizationIMPbiological_process
GO:0070937CRD-mediated mRNA stability complexIDAcellular_component
GO:0071204Histone pre-mRNA 3'end processing complexISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68220026210.39845265760.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0285360409
GSE13712_SHEARDown-0.0915435616
GSE13712_STATICDown-0.0829428661
GSE19018Up0.1502660362
GSE19899_A1Down-0.2873820100
GSE19899_A2Up0.0196741953
PubMed_21979375_A1Down-0.0853626634
PubMed_21979375_A2Down-0.4067963873
GSE35957Down-0.1014223816
GSE36640Down-0.2983715986
GSE54402Up0.1006870539
GSE9593Up0.1412636727
GSE43922Up0.0119585300
GSE24585Down-0.2318903458
GSE37065Down-0.1974622777
GSE28863_A1Down-0.0824726792
GSE28863_A2Up0.3736494434
GSE28863_A3Up0.5291338557
GSE28863_A4Up0.1173891057
GSE48662Down-0.0718398566

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-137MIMAT0000429MIRT007092Luciferase reporter assayFunctional MTI23178914
hsa-miR-124-3pMIMAT0000422MIRT022450Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-16-5pMIMAT0000069MIRT031527ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1307-3pMIMAT0005951MIRT035821CLASHFunctional MTI (Weak)23622248
hsa-miR-1292-5pMIMAT0005943MIRT035829CLASHFunctional MTI (Weak)23622248
hsa-miR-1296-5pMIMAT0005794MIRT036078CLASHFunctional MTI (Weak)23622248
hsa-miR-935MIMAT0004978MIRT036695CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037523CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039737CLASHFunctional MTI (Weak)23622248
hsa-miR-605-5pMIMAT0003273MIRT040476CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041860CLASHFunctional MTI (Weak)23622248
hsa-miR-106b-5pMIMAT0000680MIRT044272CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045400CLASHFunctional MTI (Weak)23622248
hsa-miR-34a-5pMIMAT0000255MIRT047343CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050297CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050595CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26168478YB1, a transcription factor, also represses the p16 transcription through direct association with its promoter region
24165022YB1 binds to and represses the p16 tumor suppressor gene
24165022Y box binding protein 1 (YB1) has multiple functions associated with drug resistance, cell proliferation and metastasis through transcriptional and translational regulation
24165022Increased expression of YB1 is closely related to tumor growth and aggressiveness
24165022We showed that YB1 protein levels were decreased through replicative and premature senescence and were correlated with increased expression levels of p16(INK) (4A) tumor suppressor gene
24165022Depletion of YB1 was associated with increased levels of p16 in human and murine primary cells
24165022Forced expression of YB1 in mouse embryonic fibroblasts resulted in decreased expression of p16 and increased cell proliferation
24165022Chromatin immunoprecipitation assays showed that YB1 directly associates with the p16 promoter
24165022Taken together, all our findings indicate that YB1 directly binds to and represses p16 transcription, subsequently resulting in the promotion of cell growth and prevention of cellular senescence
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