HCSGD entry for ACR
1. General information
| Official gene symbol | ACR |
|---|---|
| Entrez ID | 49 |
| Gene full name | acrosin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002077 | Acrosome matrix dispersal | NAS | biological_process |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0004040 | Amidase activity | ISS | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IDA IEA | molecular_function |
| GO:0005507 | Copper ion binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005537 | Mannose binding | IDA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005798 | Golgi-associated vesicle | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007190 | Activation of adenylate cyclase activity | IDA | biological_process |
| GO:0007338 | Single fertilization | ISS TAS | biological_process |
| GO:0007339 | Binding of sperm to zona pellucida | IEA | biological_process |
| GO:0007340 | Acrosome reaction | IMP TAS | biological_process |
| GO:0007341 | Penetration of zona pellucida | IDA | biological_process |
| GO:0008144 | Drug binding | ISS | molecular_function |
| GO:0008270 | Zinc ion binding | NAS | molecular_function |
| GO:0032504 | Multicellular organism reproduction | TAS | biological_process |
| GO:0042806 | Fucose binding | ISS | molecular_function |
| GO:0043159 | Acrosomal matrix | TAS | cellular_component |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0048545 | Response to steroid hormone | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4916853729 | 0.8538648608 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0999315343 |
| GSE13712_SHEAR | Down | -0.2663528969 |
| GSE13712_STATIC | Down | -0.0470356230 |
| GSE19018 | Up | 0.0915130594 |
| GSE19899_A1 | Up | 0.0145931224 |
| GSE19899_A2 | Up | 0.1257896320 |
| PubMed_21979375_A1 | Up | 0.3461445878 |
| PubMed_21979375_A2 | Up | 0.1297032007 |
| GSE35957 | Up | 0.0552981291 |
| GSE36640 | Down | -0.0175864006 |
| GSE54402 | Down | -0.0899523678 |
| GSE9593 | Down | -0.1016566806 |
| GSE43922 | Up | 0.1151503011 |
| GSE24585 | Up | 0.1022360563 |
| GSE37065 | Up | 0.0499373508 |
| GSE28863_A1 | Up | 0.0372158044 |
| GSE28863_A2 | Down | -0.1846917153 |
| GSE28863_A3 | Up | 0.3687778239 |
| GSE28863_A4 | Up | 0.0987399902 |
| GSE48662 | Up | 0.1021307587 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018926 | Microarray | Functional MTI (Weak) | 18185580 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25531190 | In this study, we examined the effects of acrylamide (ACR), a genotoxic carcinogen, on cellular senescence and the molecular mechanisms of ATF3 function in macrophages |
| 25531190 | Treatment of macrophages with ACR at low concentrations (<1 |
| 25531190 | Exposure of macrophages to ACR led to stress-induced, telomerase-independent senescence |
| 25531190 | In addition, ACR treatment for 1, 3, or 5 days showed a concentration-dependent increase in ATF3 expression and G0/G1 phase arrest |
| 25531190 | To better understand the role of ATF3 in controlling the senescence response to ACR, SA-beta-gal activity was examined using ATF3 knockdown and overexpression |
| 25531190 | ATF3 also played an important role in regulating intracellular reactive oxygen species (ROS) production in response to ACR treatment |
| 20832529 | BACKGROUND: Late versus early acute antibody-mediated rejection (AAMR) or acute cellular rejection (ACR) episodes are associated with poorer kidney function and graft survival |
| 20832529 | We explored whether cell senescence upon detection of AAMR +/- ACR contributes to these results |
| 20832529 | Biopsies performed for acute graft dysfunction from January 2000 to March 2007 were analyzed for morphological criteria of AAMR with or without ACR (n = 17 from 17 patients) |
| 20832529 | 3 cells/HPF in 4 of 8 biopsies performed at a median of 23 (range = 4-80) days (early AAMR +/- ACR), and 59 |
| 20832529 | 3 cells/HPF in 5 of 9 biopsies performed at a median of 1171 (range = 279-3210) days (late AAMR +/- ACR) |
| 17407150 | This may be partly attributed to age-dependent changes in the lipid peroxidation product acrolein (ACR), which was abundant at older ages in non-administered cells, but scarcely in TocP-administered cells |
Entries Per Page
Displaying Page of
