HCSGD entry for NRF1

1. General information

Official gene symbolNRF1
Entrez ID4899
Gene full namenuclear respiratory factor 1
Other gene symbolsALPHA-PAL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006091Generation of precursor metabolites and energyTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051593Response to folic acidIEAbiological_process
GO:0051602Response to electrical stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70246960220.52245372900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0496567238
GSE13712_SHEARUp0.0749433450
GSE13712_STATICUp0.0608912614
GSE19018Down-0.1258943982
GSE19899_A1Down-0.0578084807
GSE19899_A2Down-0.1402327313
PubMed_21979375_A1Up0.7743109927
PubMed_21979375_A2Down-0.1611648615
GSE35957Down-0.1248849889
GSE36640Down-0.6394868760
GSE54402Up0.1715060138
GSE9593Down-0.1601046812
GSE43922Up0.1418640322
GSE24585Down-0.1759673467
GSE37065Up0.1651180937
GSE28863_A1Up0.1412109685
GSE28863_A2Up0.3914424549
GSE28863_A3Up0.0234529878
GSE28863_A4Down-0.0995291769
GSE48662Down-0.1380244576

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022754MicroarrayFunctional MTI (Weak)18668037
hsa-miR-320aMIMAT0000510MIRT044600CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25970806We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPbeta1, in decision making between the choices of inducing cell aging and immortality
25792330Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation
23159434Furthermore, the overexpression of PGC-1alpha induced by transfection largely increased the expression levels of NRF-1 and TFAM and significantly decreased the expression level of NF-kappaB in the cell senescence model
12372989On the other hand, the mRNA levels of many nuclear DNA-encoded proteins involved in mitochondrial biogenesis, particularly nuclear respiratory factor-1, were found to increase in cells in later proliferation stages and in cells in early proliferation stages that had been treated with 180 microM H(2)O(2)
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