HCSGD entry for NRAS

1. General information

Official gene symbolNRAS
Entrez ID4893
Gene full nameneuroblastoma RAS viral (v-ras) oncogene homolog
Other gene symbolsALPS4 N-ras NRAS1 NS6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0000165MAPK cascadeTASbiological_process
GO:0000186Activation of MAPKK activityTASbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008542Visual learningIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0032228Regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0035022Positive regulation of Rac protein signal transductionIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048169Regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051146Striated muscle cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99500666010.00331622660.99999024730.1163384820

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6194795654
GSE13712_SHEARUp0.2312276942
GSE13712_STATICDown-0.0617791764
GSE19018Down-0.7822689356
GSE19899_A1Down-1.1074422029
GSE19899_A2Down-1.2781020276
PubMed_21979375_A1Down-0.5639828998
PubMed_21979375_A2Down-0.9386169621
GSE35957Down-0.3663841808
GSE36640Down-1.0401505387
GSE54402Up0.0079577391
GSE9593Down-0.3356543644
GSE43922Down-0.3791706150
GSE24585Down-0.0910155090
GSE37065Down-0.3090930538
GSE28863_A1Down-0.0948799282
GSE28863_A2Up0.3978324436
GSE28863_A3Down-0.5428979256
GSE28863_A4Down-0.2172330750
GSE48662Down-0.4049947490

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7a-5pMIMAT0000062MIRT001854Western blotFunctional MTI19110058
hsa-let-7a-5pMIMAT0000062MIRT001854Luciferase reporter assay//MicroarrayFunctional MTI15766527
hsa-let-7b-5pMIMAT0000063MIRT003836Luciferase reporter assayFunctional MTI17699775
hsa-let-7b-5pMIMAT0000063MIRT003836Immunohistochemistry//qRT-PCRFunctional MTI (Weak)19966857
hsa-let-7b-5pMIMAT0000063MIRT003836ProteomicsFunctional MTI (Weak)18668040
hsa-miR-20a-5pMIMAT0000075MIRT003903Western blotNon-Functional MTI19110058
hsa-let-7c-5pMIMAT0000064MIRT004531Microarray//Northern blot//qRT-PCR//Western blotFunctional MTI15766527
hsa-miR-145-5pMIMAT0000437MIRT007107Luciferase reporter assay//Western blotFunctional MTI23201159
hsa-miR-148b-3pMIMAT0000759MIRT007317Western blotFunctional MTI23238785
hsa-miR-124-3pMIMAT0000422MIRT023141Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-98-5pMIMAT0000096MIRT027862MicroarrayFunctional MTI (Weak)19088304
hsa-miR-877-3pMIMAT0004950MIRT037130CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-let-7a-5pMIMAT00000623hsa-let-7a15766527
hsa-let-7a-5pMIMAT00000627hsa-let-7a15766527
hsa-let-7a-5pMIMAT00000628hsa-let-7a15766527
hsa-let-7a-5pMIMAT00000626hsa-let-7a15766527
hsa-let-7a-5pMIMAT00000622hsa-let-7a15766527
hsa-let-7a-5pMIMAT00000625hsa-let-7a15766527
hsa-let-7a-5pMIMAT00000624hsa-let-7a15766527
hsa-let-7a-5pMIMAT00000629hsa-let-7a15766527
hsa-let-7a-5pMIMAT00000621hsa-let-7a15766527
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26152738When death receptors were activated in senescent tumor cells, both intrinsic and extrinsic apoptotic pathways were induced independent of BRAF, NRAS, or p53 mutation status
23949765Making a mountain out of a molehill: NRAS, mosaicism, and large congenital nevi
23904845No pathogenetic mutations in CDKN2A, BRAF, NRAS, KRAS, cKIT, TP53 and PTEN genes were observed
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