HCSGD entry for NPR2

1. General information

Official gene symbolNPR2
Entrez ID4882
Gene full namenatriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
Other gene symbolsAMDM ANPRB ANPb GUC2B GUCY2B NPRB NPRBi
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0004383Guanylate cyclase activityIDA IEAmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005886Plasma membraneIEAcellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007168Receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0008217Regulation of blood pressureTASbiological_process
GO:0009190Cyclic nucleotide biosynthetic processIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0016849Phosphorus-oxygen lyase activityIEAmolecular_function
GO:0016941Natriuretic peptide receptor activityIDAmolecular_function
GO:0017046Peptide hormone bindingIEAmolecular_function
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042562Hormone bindingIPImolecular_function
GO:0042802Identical protein bindingIEAmolecular_function
GO:0060348Bone developmentIEAbiological_process
GO:0097011Cellular response to granulocyte macrophage colony-stimulating factor stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02496427570.80697808970.37228482451.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1017335686
GSE13712_SHEARUp0.3566650735
GSE13712_STATICUp0.2639729115
GSE19018Up0.5024149362
GSE19899_A1Down-0.2927112291
GSE19899_A2Up0.1530362890
PubMed_21979375_A1Down-0.5830618313
PubMed_21979375_A2Up0.6529273111
GSE35957Up0.0555724600
GSE36640Up0.9285539605
GSE54402Down-0.3396496184
GSE9593Up0.4174668529
GSE43922Down-0.0346460498
GSE24585Down-0.0291139430
GSE37065Up0.0571555724
GSE28863_A1Up1.5997165410
GSE28863_A2Up0.5824529979
GSE28863_A3Up0.0119554622
GSE28863_A4Down-0.0148564980
GSE48662Up0.2769229678

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NesiritideDB04899 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.