HCSGD entry for NPR1

1. General information

Official gene symbolNPR1
Entrez ID4881
Gene full namenatriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Other gene symbolsANPRA ANPa GUC2A GUCY2A NPRA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004383Guanylate cyclase activityIDAmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005887Integral component of plasma membraneICcellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0007166Cell surface receptor signaling pathwayNASbiological_process
GO:0007168Receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayNASbiological_process
GO:0007589Body fluid secretionTASbiological_process
GO:0008217Regulation of blood pressureNASbiological_process
GO:0008528G-protein coupled peptide receptor activityNASmolecular_function
GO:0016525Negative regulation of angiogenesisTASbiological_process
GO:0016941Natriuretic peptide receptor activityIDAmolecular_function
GO:0017046Peptide hormone bindingIEAmolecular_function
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030308Negative regulation of cell growthNASbiological_process
GO:0030828Positive regulation of cGMP biosynthetic processIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0035810Positive regulation of urine volumeTASbiological_process
GO:0035815Positive regulation of renal sodium excretionTASbiological_process
GO:0042312Regulation of vasodilationNASbiological_process
GO:0042417Dopamine metabolic processIEAbiological_process
GO:0042562Hormone bindingIPImolecular_function
GO:0043114Regulation of vascular permeabilityTASbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0048662Negative regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050880Regulation of blood vessel sizeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74324379770.21102036400.99999024730.8868141284

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1397915409
GSE13712_SHEARDown-2.4000056712
GSE13712_STATICDown-1.1705249936
GSE19018Up0.0670814325
GSE19899_A1Down-0.0035204790
GSE19899_A2Up0.1793196025
PubMed_21979375_A1Down-0.0870359871
PubMed_21979375_A2Up0.1403750888
GSE35957Up0.2252240215
GSE36640Up0.0691064267
GSE54402Down-0.0006805871
GSE9593Up0.0160786898
GSE43922Up0.2271764536
GSE24585Down-0.1813988273
GSE37065Up0.0332904988
GSE28863_A1Up0.0668874085
GSE28863_A2Up0.1007566741
GSE28863_A3Up0.1742592178
GSE28863_A4Up0.0905111500
GSE48662Down-0.0564134692

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NitroprussideDB00325 APRD01143
Amyl NitriteDB01612 -
NesiritideDB04899 -
UlaritideDB05034 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320aMIMAT0000510MIRT006575Luciferase reporter assay//Western blotFunctional MTI22134529
hsa-miR-124-3pMIMAT0000422MIRT022739MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.