HCSGD entry for NOTCH2
1. General information
| Official gene symbol | NOTCH2 |
|---|---|
| Entrez ID | 4853 |
| Gene full name | notch 2 |
| Other gene symbols | AGS2 HJCYS hN2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001709 | Cell fate determination | TAS | biological_process |
| GO:0002011 | Morphogenesis of an epithelial sheet | IEA | biological_process |
| GO:0002437 | Inflammatory response to antigenic stimulus | IEA | biological_process |
| GO:0003184 | Pulmonary valve morphogenesis | IMP | biological_process |
| GO:0004872 | Receptor activity | NAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006959 | Humoral immune response | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | IDA | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007220 | Notch receptor processing | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | NAS | biological_process |
| GO:0007368 | Determination of left/right symmetry | IEA | biological_process |
| GO:0007399 | Nervous system development | NAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0009887 | Organ morphogenesis | IEP | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016049 | Cell growth | IDA | biological_process |
| GO:0019827 | Stem cell maintenance | TAS | biological_process |
| GO:0030097 | Hemopoiesis | TAS | biological_process |
| GO:0030326 | Embryonic limb morphogenesis | IEA | biological_process |
| GO:0030522 | Intracellular receptor signaling pathway | TAS | biological_process |
| GO:0038049 | Ligand-activated RNA polymerase II transcription factor binding transcription factor activity | TAS | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0046579 | Positive regulation of Ras protein signal transduction | IDA | biological_process |
| GO:0046849 | Bone remodeling | IMP | biological_process |
| GO:0060413 | Atrial septum morphogenesis | IMP | biological_process |
| GO:0060674 | Placenta blood vessel development | IEA | biological_process |
| GO:0061314 | Notch signaling involved in heart development | IC | biological_process |
| GO:0072602 | Interleukin-4 secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0227729114 | 0.6090900574 | 0.3606136091 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3832895047 |
| GSE13712_SHEAR | Up | 0.3344178208 |
| GSE13712_STATIC | Up | 0.2138479797 |
| GSE19018 | Up | 0.3264463444 |
| GSE19899_A1 | Down | -0.0730685034 |
| GSE19899_A2 | Up | 0.2674667579 |
| PubMed_21979375_A1 | Down | -0.2651676765 |
| PubMed_21979375_A2 | Down | -0.1859662999 |
| GSE35957 | Down | -0.3037275592 |
| GSE36640 | Up | 0.1878185972 |
| GSE54402 | Up | 0.1568810629 |
| GSE9593 | Up | 0.3992439149 |
| GSE43922 | Up | 0.1855769191 |
| GSE24585 | Up | 0.1296317279 |
| GSE37065 | Up | 0.3407794154 |
| GSE28863_A1 | Up | 1.8329789851 |
| GSE28863_A2 | Up | 1.9235682406 |
| GSE28863_A3 | Down | -0.1424051934 |
| GSE28863_A4 | Down | -0.3331070957 |
| GSE48662 | Down | -0.2323405301 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001353 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT001353 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001437 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-181c-5p | MIMAT0000258 | MIRT003209 | Luciferase reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 20080834 |
| hsa-miR-326 | MIMAT0000756 | MIRT004425 | Western blot//Luciferase reporter assay | Functional MTI | 19955368 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT005029 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19773441 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT005029 | Immunoblot//Immunocytochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 22363487 |
| hsa-miR-107 | MIMAT0000104 | MIRT007156 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23299462 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020879 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT025026 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025208 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037594 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-130b-5p | MIMAT0004680 | MIRT038296 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046195 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048264 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048329 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049544 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050287 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050936 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051850 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | 1 | hsa-miR-34a | {Western blot} | {overexpression by miRNA precursor transfection} | 19773441 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
