HCSGD entry for NOTCH1

1. General information

Official gene symbolNOTCH1
Entrez ID4851
Gene full namenotch 1
Other gene symbolsTAN1 hN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0001047Core promoter bindingISSmolecular_function
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001708Cell fate specificationIEAbiological_process
GO:0001837Epithelial to mesenchymal transitionISSbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0002040Sprouting angiogenesisIEAbiological_process
GO:0002193MAML1-RBP-Jkappa- ICN1 complexIDAcellular_component
GO:0002437Inflammatory response to antigenic stimulusIEAbiological_process
GO:0003157Endocardium developmentISSbiological_process
GO:0003160Endocardium morphogenesisISSbiological_process
GO:0003162Atrioventricular node developmentIEAbiological_process
GO:0003169Coronary vein morphogenesisISSbiological_process
GO:0003180Aortic valve morphogenesisIMPbiological_process
GO:0003181Atrioventricular valve morphogenesisISSbiological_process
GO:0003184Pulmonary valve morphogenesisIMPbiological_process
GO:0003192Mitral valve formationIMPbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationISSbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003207Cardiac chamber formationISSbiological_process
GO:0003208Cardiac ventricle morphogenesisISSbiological_process
GO:0003209Cardiac atrium morphogenesisISSbiological_process
GO:0003213Cardiac right atrium morphogenesisISSbiological_process
GO:0003214Cardiac left ventricle morphogenesisISSbiological_process
GO:0003219Cardiac right ventricle formationIEAbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisISSbiological_process
GO:0003241Growth involved in heart morphogenesisISSbiological_process
GO:0003256Regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationISSbiological_process
GO:0003270Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferationIEAbiological_process
GO:0003273Cell migration involved in endocardial cushion formationISSbiological_process
GO:0003344Pericardium morphogenesisISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0004857Enzyme inhibitor activityISSmolecular_function
GO:0004872Receptor activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005634NucleusISS TAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006955Immune responseNASbiological_process
GO:0006959Humoral immune responseIEAbiological_process
GO:0007219Notch signaling pathwayIMP TASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0007221Positive regulation of transcription of Notch receptor targetISSbiological_process
GO:0007368Determination of left/right symmetryISSbiological_process
GO:0007386Compartment pattern specificationIEAbiological_process
GO:0007409AxonogenesisIEAbiological_process
GO:0007440Foregut morphogenesisIEAbiological_process
GO:0007492Endoderm developmentIEAbiological_process
GO:0007507Heart developmentIMPbiological_process
GO:0008284Positive regulation of cell proliferationIDA IMPbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0009912Auditory receptor cell fate commitmentIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010001Glial cell differentiationIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0010812Negative regulation of cell-substrate adhesionIDAbiological_process
GO:0010832Negative regulation of myotube differentiationISSbiological_process
GO:0014031Mesenchymal cell developmentISSbiological_process
GO:0014807Regulation of somitogenesisIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0019899Enzyme bindingISSmolecular_function
GO:0021915Neural tube developmentIEAbiological_process
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0030279Negative regulation of ossificationISSbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030335Positive regulation of cell migrationISSbiological_process
GO:0030513Positive regulation of BMP signaling pathwayISSbiological_process
GO:0030514Negative regulation of BMP signaling pathwayISSbiological_process
GO:0030900Forebrain developmentIEAbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0031490Chromatin DNA bindingIEAmolecular_function
GO:0032495Response to muramyl dipeptideIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035148Tube formationIMPbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIDAbiological_process
GO:0042640AnagenIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043086Negative regulation of catalytic activityISSbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045618Positive regulation of keratinocyte differentiationIEAbiological_process
GO:0045662Negative regulation of myoblast differentiationIMPbiological_process
GO:0045668Negative regulation of osteoblast differentiationISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0045955Negative regulation of calcium ion-dependent exocytosisIEAbiological_process
GO:0046427Positive regulation of JAK-STAT cascadeISSbiological_process
GO:0046533Negative regulation of photoreceptor cell differentiationIEAbiological_process
GO:0048103Somatic stem cell divisionIEAbiological_process
GO:0048711Positive regulation of astrocyte differentiationISSbiological_process
GO:0048715Negative regulation of oligodendrocyte differentiationISSbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0050768Negative regulation of neurogenesisISSbiological_process
GO:0055008Cardiac muscle tissue morphogenesisISSbiological_process
GO:0060038Cardiac muscle cell proliferationIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationISSbiological_process
GO:0060253Negative regulation of glial cell proliferationISSbiological_process
GO:0060271Cilium morphogenesisISSbiological_process
GO:0060317Cardiac epithelial to mesenchymal transitionISSbiological_process
GO:0060411Cardiac septum morphogenesisISSbiological_process
GO:0060412Ventricular septum morphogenesisIMPbiological_process
GO:0060528Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentIEAbiological_process
GO:0060740Prostate gland epithelium morphogenesisIEAbiological_process
GO:0060768Regulation of epithelial cell proliferation involved in prostate gland developmentIEAbiological_process
GO:0060842Arterial endothelial cell differentiationISSbiological_process
GO:0060843Venous endothelial cell differentiationISSbiological_process
GO:0060948Cardiac vascular smooth muscle cell developmentISSbiological_process
GO:0060956Endocardial cell differentiationISSbiological_process
GO:0060979Vasculogenesis involved in coronary vascular morphogenesisISSbiological_process
GO:0060982Coronary artery morphogenesisISSbiological_process
GO:0061314Notch signaling involved in heart developmentIMPbiological_process
GO:0061384Heart trabecula morphogenesisISSbiological_process
GO:0061419Positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaISSbiological_process
GO:0070986Left/right axis specificationIEAbiological_process
GO:0071372Cellular response to follicle-stimulating hormone stimulusIDAbiological_process
GO:0072017Distal tubule developmentIEAbiological_process
GO:0072044Collecting duct developmentIEAbiological_process
GO:0072144Glomerular mesangial cell developmentIEAbiological_process
GO:0072602Interleukin-4 secretionIEAbiological_process
GO:0090051Negative regulation of cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:0097150Neuronal stem cell maintenanceIEPbiological_process
GO:1901201Regulation of extracellular matrix assemblyISSbiological_process
GO:1902263Apoptotic process involved in embryonic digit morphogenesisIEAbiological_process
GO:2000737Negative regulation of stem cell differentiationIMPbiological_process
GO:2000811Negative regulation of anoikisIMPbiological_process
GO:2000974Negative regulation of pro-B cell differentiationISSbiological_process
GO:2001027Negative regulation of endothelial cell chemotaxisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05619905400.95501988530.51510866991.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0172981014
GSE13712_SHEARDown-0.0322831321
GSE13712_STATICDown-0.2394013362
GSE19018Down-0.0696686924
GSE19899_A1Up0.0799117540
GSE19899_A2Up0.2849568599
PubMed_21979375_A1Up0.4662107936
PubMed_21979375_A2Up0.1673424612
GSE35957Down-0.0555443885
GSE36640Down-0.0329681203
GSE54402Up0.4107090536
GSE9593Down-0.1578837299
GSE43922Up0.5249308875
GSE24585Up0.6469522559
GSE37065Down-0.0457476852
GSE28863_A1Up0.2336808256
GSE28863_A2Up0.4506804622
GSE28863_A3Up0.1589674705
GSE28863_A4Up0.1161984726
GSE48662Up0.1269259578

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34c-5pMIMAT0000686MIRT006459Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22498974
hsa-miR-34b-3pMIMAT0004676MIRT006458Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22498974
hsa-miR-449aMIMAT0001541MIRT006446ChIP-seq//Luciferase reporter assayFunctional MTI21569010
hsa-miR-27b-3pMIMAT0000419MIRT001768Reporter assayFunctional MTI17150773
hsa-miR-27b-3pMIMAT0000419MIRT001768CLASHFunctional MTI (Weak)23622248
hsa-miR-24-3pMIMAT0000080MIRT001773Reporter assayFunctional MTI15131085
hsa-miR-23b-3pMIMAT0000418MIRT001775Reporter assayFunctional MTI17150773
hsa-miR-34a-5pMIMAT0000255MIRT002875Luciferase reporter assayFunctional MTI14697198
hsa-miR-34a-5pMIMAT0000255MIRT002875MicroarrayFunctional MTI (Weak)19461653
hsa-miR-34a-5pMIMAT0000255MIRT002875Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20351093
hsa-miR-34a-5pMIMAT0000255MIRT002875Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19773441
hsa-miR-34a-5pMIMAT0000255MIRT002875Luciferase reporter assay//MicroarrayFunctional MTI17150773
hsa-miR-34a-5pMIMAT0000255MIRT002875Immunofluorescence//Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22363487
hsa-miR-34a-5pMIMAT0000255MIRT002875Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22684561
hsa-miR-34a-5pMIMAT0000255MIRT002875Luciferase reporter assayFunctional MTI23085450
hsa-miR-34a-5pMIMAT0000255MIRT002875Western blotFunctional MTI23226240
hsa-miR-30a-5pMIMAT0000087MIRT002876Luciferase reporter assay//MicroarrayFunctional MTI17150773
hsa-miR-326MIMAT0000756MIRT004424Western blot//Luciferase reporter assayFunctional MTI19955368
hsa-miR-129-5pMIMAT0000242MIRT005412Luciferase reporter assay//MicroarrayFunctional MTI17150773
hsa-miR-144-3pMIMAT0000436MIRT005869Luciferase reporter assayFunctional MTI21285251
hsa-miR-10b-5pMIMAT0000254MIRT006924Luciferase reporter assayFunctional MTI23034333
hsa-miR-181a-5pMIMAT0000256MIRT035538Luciferase reporter assay//Western blotFunctional MTI22916024
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-34a-5pMIMAT00002551hsa-miR-34a14697198
hsa-miR-34a-5pMIMAT00002552hsa-miR-34a14697198
hsa-miR-34a-5pMIMAT00002554hsa-miR-34a14697198
hsa-miR-34a-5pMIMAT00002553hsa-miR-34a14697198
hsa-miR-34a-5pMIMAT0000255NAhsa-miR-34a{Western blot}{overexpression by miRNA precursor transfection}20351093
hsa-miR-34a-5pMIMAT00002551hsa-miR-34a{Western blot}{overexpression by miRNA precursor transfection}19773441
hsa-miR-34a-5pMIMAT00002552hsa-miR-34a{Western blot}{overexpression by miRNA precursor transfection}19773441
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26650241Deregulated expression of Notch1 and Jagged1 is observed in colorectal cancer
26629698Several key genetic alterations have been identified including the near ubiquitous loss of the CDKN2A/p16INK4A and p53 pathways and telomerase activation, together with frequent inactivation of the NOTCH1 canonical pathway either by somatic genetic alterations or by the presence of human papilloma virus
24950189Conversely, over-expression of Notch1 or Jagged1 prolonged the replicative lifespan of endothelial cells
24950189Notch1 positively regulated the expression of inhibitor of DNA binding 1 (Id1) and MAP kinase phosphatase 1 (MKP1), while MKP1 further up-regulated Id1 expression by inhibiting p38MAPK-induced protein degradation
24950189These findings indicate that Notch1 signaling has a role in the regulation of endothelial cell senescence via a p16-dependent pathway and suggest that activation of Notch1 could be a new therapeutic target for treating age-associated vascular diseases
24931169When expressed in a tetracycline-inducible manner, the ectopically expressed activated form of Notch1 (ICN1) displayed oncogene-like characteristics inducing cellular senescence corroborated by the induction of G0/G1 cell-cycle arrest, Rb dephosphorylation, flat and enlarged cell morphology and senescence-associated beta-galactosidase activity
24931169Moreover, Notch1 appears to mediate replicative senescence as well as transforming growth factor-beta-induced cellular senescence in non-transformed cells and that HPV E6/E7 targets Notch1 for inactivation to prevent senescence, revealing a tumor-suppressor attribute of endogenous Notch1
24573392In this study, we found that activation of tubular epithelial Notch1 signaling was prolonged in the aging kidney after ischemia/reperfusion (IR) damage
24109236Microarray analysis revealed enhanced expression of Notch1 mRNA in 16E6-expressing keratinocytes when NFX1-123 was overexpressed
24109236A moderate increase in Notch1 mRNA was seen with overexpression of NFX1-123 alone, but with 16E6 coexpression the increase in Notch1 was enhanced
24109236The PAM2 motif and R3H protein domains in NFX1-123, which were important for increased hTERT expression, were also important in the augmentation of Notch1 expression by 16E6
20578140Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage
20578140These effects were due to a reduction of Notch1 cleavage by HBx through the suppression of presenilin1 (Psen1) transcription rather than inhibition of Notch1 transcription or its ligands' expression
20578140CONCLUSION: Our results reveal a novel function of HBx in blunting senescence-like growth arrest by decreasing Notch1 signaling, which could be a putative molecular mechanism mediating HBV-associated hepatocarcinogenesis
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