HCSGD entry for CNOT2

1. General information

Official gene symbolCNOT2
Entrez ID4848
Gene full nameCCR4-NOT transcription complex, subunit 2
Other gene symbolsCDC36 NOT2 NOT2H
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000289Nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0001104RNA polymerase II transcription cofactor activityTASmolecular_function
GO:0001226RNA polymerase II transcription corepressor bindingIDAmolecular_function
GO:0001829Trophectodermal cell differentiationIEAbiological_process
GO:0004535Poly(A)-specific ribonuclease activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA NAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterNASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006417Regulation of translationIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010606Positive regulation of cytoplasmic mRNA processing body assemblyIMPbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0030014CCR4-NOT complexIDAcellular_component
GO:0031047Gene silencing by RNAIEAbiological_process
GO:0033147Negative regulation of intracellular estrogen receptor signaling pathwayIMPbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisIMPbiological_process
GO:0090501RNA phosphodiester bond hydrolysisIMPbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticIMPbiological_process
GO:2000036Regulation of stem cell maintenanceIEA IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95479140230.23417269860.99999024730.9319804657

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1923493893
GSE13712_SHEARDown-0.0422186714
GSE13712_STATICDown-0.1052452473
GSE19018Down-0.0453551396
GSE19899_A1Down-0.0219606778
GSE19899_A2Down-0.0780952487
PubMed_21979375_A1Down-0.1774587872
PubMed_21979375_A2Up0.1276964984
GSE35957Down-0.0234529815
GSE36640Down-0.2999111450
GSE54402Up0.1154450365
GSE9593Down-0.2712031758
GSE43922Down-0.1130991352
GSE24585Up0.0923914657
GSE37065Up0.1174163636
GSE28863_A1Up0.0578021505
GSE28863_A2Down-0.1464790926
GSE28863_A3Down-0.5880361480
GSE28863_A4Up0.0971614198
GSE48662Down-0.0200442838

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-301bMIMAT0004958MIRT036704CLASHFunctional MTI (Weak)23622248
hsa-miR-361-5pMIMAT0000703MIRT044094CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051943CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.