HCSGD entry for NOS3
1. General information
| Official gene symbol | NOS3 |
|---|---|
| Entrez ID | 4846 |
| Gene full name | nitric oxide synthase 3 (endothelial cell) |
| Other gene symbols | ECNOS eNOS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001542 | Ovulation from ovarian follicle | IEA | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001974 | Blood vessel remodeling | IEA ISS | biological_process |
| GO:0002028 | Regulation of sodium ion transport | IEA | biological_process |
| GO:0003057 | Regulation of the force of heart contraction by chemical signal | IEA | biological_process |
| GO:0003100 | Regulation of systemic arterial blood pressure by endothelin | IMP | biological_process |
| GO:0003785 | Actin monomer binding | IPI | molecular_function |
| GO:0003958 | NADPH-hemoprotein reductase activity | IBA | molecular_function |
| GO:0004517 | Nitric-oxide synthase activity | IDA IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005901 | Caveola | IDA | cellular_component |
| GO:0006527 | Arginine catabolic process | IDA | biological_process |
| GO:0006809 | Nitric oxide biosynthetic process | IDA IEA | biological_process |
| GO:0007005 | Mitochondrion organization | ISS | biological_process |
| GO:0007263 | Nitric oxide mediated signal transduction | IBA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008217 | Regulation of blood pressure | NAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA ISS | biological_process |
| GO:0009408 | Response to heat | NAS | biological_process |
| GO:0010181 | FMN binding | IEA NAS | molecular_function |
| GO:0010544 | Negative regulation of platelet activation | NAS | biological_process |
| GO:0014740 | Negative regulation of muscle hyperplasia | IEA ISS | biological_process |
| GO:0014806 | Smooth muscle hyperplasia | IEA ISS | biological_process |
| GO:0020037 | Heme binding | IDA IEA | molecular_function |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0030666 | Endocytic vesicle membrane | TAS | cellular_component |
| GO:0031284 | Positive regulation of guanylate cyclase activity | IMP ISS | biological_process |
| GO:0031663 | Lipopolysaccharide-mediated signaling pathway | IEA | biological_process |
| GO:0034405 | Response to fluid shear stress | IEP | biological_process |
| GO:0034617 | Tetrahydrobiopterin binding | IDA | molecular_function |
| GO:0034618 | Arginine binding | IDA | molecular_function |
| GO:0043267 | Negative regulation of potassium ion transport | IEA | biological_process |
| GO:0043542 | Endothelial cell migration | IMP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IEA ISS | biological_process |
| GO:0045776 | Negative regulation of blood pressure | IBA | biological_process |
| GO:0045909 | Positive regulation of vasodilation | NAS | biological_process |
| GO:0046209 | Nitric oxide metabolic process | TAS | biological_process |
| GO:0046870 | Cadmium ion binding | NAS | molecular_function |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA NAS | molecular_function |
| GO:0050661 | NADP binding | IEA NAS | molecular_function |
| GO:0050880 | Regulation of blood vessel size | IEA ISS NAS | biological_process |
| GO:0050999 | Regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:0051346 | Negative regulation of hydrolase activity | IEA | biological_process |
| GO:0051701 | Interaction with host | TAS | biological_process |
| GO:0051926 | Negative regulation of calcium ion transport | IEA | biological_process |
| GO:0090382 | Phagosome maturation | TAS | biological_process |
| GO:1902042 | Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2320452642 | 0.8511961286 | 0.9156997153 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1071932732 |
| GSE13712_SHEAR | Down | -0.1767943745 |
| GSE13712_STATIC | Up | 0.0160093670 |
| GSE19018 | Up | 0.1785090870 |
| GSE19899_A1 | Up | 0.1066325569 |
| GSE19899_A2 | Up | 0.0530597009 |
| PubMed_21979375_A1 | Up | 0.2105512692 |
| PubMed_21979375_A2 | Up | 0.0890202085 |
| GSE35957 | Up | 0.0425493765 |
| GSE36640 | Up | 0.0108230257 |
| GSE54402 | Up | 0.0952317162 |
| GSE9593 | Up | 0.0161258487 |
| GSE43922 | Up | 0.1153000858 |
| GSE24585 | Down | -0.1277366237 |
| GSE37065 | Up | 0.1503962355 |
| GSE28863_A1 | Down | -0.0902985017 |
| GSE28863_A2 | Up | 0.1410814886 |
| GSE28863_A3 | Up | 0.3249561469 |
| GSE28863_A4 | Up | 0.1685342394 |
| GSE48662 | Down | -0.1440069545 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT007181 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23108656 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017773 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25377220 | CONCLUSIONS: Aged AAP cells appear compromised in their mechanotransduction machinery involving eNOS, the protein product of the gene, NOS3, polymorphisms of which impart a risk for the development of glaucoma |
| 21784712 | Nitric oxide synthase 3 (endothelial nitric oxide synthase [eNOS]) showed a 5 |
| 19409979 | Furthermore, its diminished expression, and not that of nitric oxide synthase 3, was implicated in the insufficient NO production exhibited by senescent HUVECs under LSS conditions |
| 7575554 | To determine the mechanism of the antiatherosclerotic effect of estrogen, we investigated the effect of estrogen on endothelial nitric oxide synthase (NOS-3) |
| 7575554 | Preincubation with a physiologic concentration of 17 beta-estradiol (10(-12)-10(-8) M) over 8 hours significantly enhanced the activity of NOS-3 in endothelial cells of cultured human umblical vein (HUVEC) and of bovine aortas (BAEC) |
| 7575554 | Western blot showed a similar effect of 17 beta-estradiol on NOS-3 |
| 7575554 | Estrogen increases NOS-3 via a receptor-mediated system, and estrogen receptor, which appeared to be altered by cell senescence, could be important in the release of NO from endothelium |
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