HCSGD entry for NOS2
1. General information
| Official gene symbol | NOS2 |
|---|---|
| Entrez ID | 4843 |
| Gene full name | nitric oxide synthase 2, inducible |
| Other gene symbols | HEP-NOS INOS NOS NOS2A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0001912 | Positive regulation of leukocyte mediated cytotoxicity | TAS | biological_process |
| GO:0002227 | Innate immune response in mucosa | NAS | biological_process |
| GO:0003958 | NADPH-hemoprotein reductase activity | IBA | molecular_function |
| GO:0004517 | Nitric-oxide synthase activity | IDA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005829 | Cytosol | IMP TAS | cellular_component |
| GO:0006527 | Arginine catabolic process | IDA | biological_process |
| GO:0006801 | Superoxide metabolic process | ISS | biological_process |
| GO:0006809 | Nitric oxide biosynthetic process | IDA | biological_process |
| GO:0006954 | Inflammatory response | IBA | biological_process |
| GO:0007263 | Nitric oxide mediated signal transduction | IBA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009617 | Response to bacterium | NAS | biological_process |
| GO:0010181 | FMN binding | ISS | molecular_function |
| GO:0010629 | Negative regulation of gene expression | IGI | biological_process |
| GO:0018119 | Peptidyl-cysteine S-nitrosylation | ISS | biological_process |
| GO:0020037 | Heme binding | ISS | molecular_function |
| GO:0030863 | Cortical cytoskeleton | IEA | cellular_component |
| GO:0031284 | Positive regulation of guanylate cyclase activity | IBA | biological_process |
| GO:0034617 | Tetrahydrobiopterin binding | ISS | molecular_function |
| GO:0034618 | Arginine binding | ISS | molecular_function |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0042177 | Negative regulation of protein catabolic process | IEA | biological_process |
| GO:0042742 | Defense response to bacterium | IMP ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | ISS | molecular_function |
| GO:0043457 | Regulation of cellular respiration | TAS | biological_process |
| GO:0045776 | Negative regulation of blood pressure | IBA | biological_process |
| GO:0045909 | Positive regulation of vasodilation | IBA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050660 | Flavin adenine dinucleotide binding | ISS | molecular_function |
| GO:0050661 | NADP binding | TAS | molecular_function |
| GO:0050796 | Regulation of insulin secretion | IMP | biological_process |
| GO:0050829 | Defense response to Gram-negative bacterium | NAS | biological_process |
| GO:0051701 | Interaction with host | TAS | biological_process |
| GO:0051712 | Positive regulation of killing of cells of other organism | IMP | biological_process |
| GO:0071222 | Cellular response to lipopolysaccharide | IEA | biological_process |
| GO:0071346 | Cellular response to interferon-gamma | IEA | biological_process |
| GO:0090382 | Phagosome maturation | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9259624368 | 0.4012789370 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1256458271 |
| GSE13712_SHEAR | Down | -0.1730742084 |
| GSE13712_STATIC | Up | 0.1147464296 |
| GSE19018 | Down | -0.0300563586 |
| GSE19899_A1 | Down | -0.0856593268 |
| GSE19899_A2 | Down | -0.0422410157 |
| PubMed_21979375_A1 | Down | -0.1858964674 |
| PubMed_21979375_A2 | Up | 0.0051136278 |
| GSE35957 | Down | -0.1371278018 |
| GSE36640 | Down | -0.0015659841 |
| GSE54402 | Up | 0.0371342985 |
| GSE9593 | Up | 0.0581169150 |
| GSE43922 | Up | 0.0269620757 |
| GSE24585 | Up | 0.0701616523 |
| GSE37065 | Down | -0.0497633156 |
| GSE28863_A1 | Down | -0.1915165388 |
| GSE28863_A2 | Down | -0.1050630645 |
| GSE28863_A3 | Down | -0.0135461510 |
| GSE28863_A4 | Down | -0.1283855433 |
| GSE48662 | Down | -0.0510082618 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Entries Per Page
Displaying Page of
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | MIRT007347 | qRT-PCR//Western blot | Functional MTI | 23338972 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22970173 | We hypothesize that nitric oxide may modulate senescence in CD; epithelial cells of CD had higher levels of NOS2 expression than in UC (P = 0 |
| 22970173 | Microarrays and quantitative-PCR identified miR-21 expression associated with macrophage infiltration and NOS2 expression |
Entries Per Page
Displaying Page of
