HCSGD entry for NME2

1. General information

Official gene symbolNME2
Entrez ID4831
Gene full nameNME/NM23 nucleoside diphosphate kinase 2
Other gene symbolsNDKB NDPK-B NDPKB NM23-H2 NM23B PUF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0004550Nucleoside diphosphate kinase activityIDA IEAmolecular_function
GO:0004673Protein histidine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006183GTP biosynthetic processIEAbiological_process
GO:0006228UTP biosynthetic processIEAbiological_process
GO:0006241CTP biosynthetic processIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007229Integrin-mediated signaling pathwayIDAbiological_process
GO:0009142Nucleoside triphosphate biosynthetic processIDAbiological_process
GO:0015949Nucleobase-containing small molecule interconversionTASbiological_process
GO:0030027LamellipodiumIDAcellular_component
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045618Positive regulation of keratinocyte differentiationIMPbiological_process
GO:0045682Regulation of epidermis developmentIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050679Positive regulation of epithelial cell proliferationIMPbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:0071944Cell peripheryIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82393408690.54178007670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922Up0.0228769654
GSE24585Down-0.1966891312
GSE37065Down-0.3776515933
GSE28863_A1Down-0.0148063710
GSE28863_A2Up0.0508995990
GSE28863_A3Up0.4619101907
GSE28863_A4Up0.2877682079
GSE48662Down-0.3166922695

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1229-3pMIMAT0005584MIRT036383CLASHFunctional MTI (Weak)23622248
hsa-miR-450b-5pMIMAT0004909MIRT037769CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038030CLASHFunctional MTI (Weak)23622248
hsa-miR-125a-5pMIMAT0000443MIRT045749CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT046082CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046894CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048132CLASHFunctional MTI (Weak)23622248
hsa-miR-27a-3pMIMAT0000084MIRT050036CLASHFunctional MTI (Weak)23622248
hsa-miR-3176MIMAT0015053MIRT052795CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

11846374Moreover, quiescence and senescence can be distinguished by increased expression of Irlb, c-Myc transcription factor, and Miz-1, c-Myc-interacting Zn finger protein 1, only in the former state
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