HCSGD entry for NME1

1. General information

Official gene symbol	NME1
Entrez ID	4830
Gene full name	NME/NM23 nucleoside diphosphate kinase 1
Other gene symbols	AWD GAAD NB NBS NDKA NDPK-A NDPKA NM23 NM23-H1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000287	Magnesium ion binding	IDA	molecular_function
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA	molecular_function
GO:0002762	Negative regulation of myeloid leukocyte differentiation	IEA	biological_process
GO:0003697	Single-stranded DNA binding	IEA	molecular_function
GO:0004536	Deoxyribonuclease activity	IDA	molecular_function
GO:0004550	Nucleoside diphosphate kinase activity	IDA IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IDA IEA	molecular_function
GO:0005525	GTP binding	IDA	molecular_function
GO:0005634	Nucleus	IDA TAS	cellular_component
GO:0005737	Cytoplasm	IDA TAS	cellular_component
GO:0005813	Centrosome	IEA	cellular_component
GO:0005829	Cytosol	IDA IEA TAS	cellular_component
GO:0006183	GTP biosynthetic process	IEA	biological_process
GO:0006228	UTP biosynthetic process	IEA	biological_process
GO:0006241	CTP biosynthetic process	IEA	biological_process
GO:0006308	DNA catabolic process	IDA	biological_process
GO:0006897	Endocytosis	IEA	biological_process
GO:0008285	Negative regulation of cell proliferation	TAS	biological_process
GO:0010629	Negative regulation of gene expression	IEA	biological_process
GO:0010976	Positive regulation of neuron projection development	IEA	biological_process
GO:0014075	Response to amine	IEA	biological_process
GO:0015949	Nucleobase-containing small molecule interconversion	TAS	biological_process
GO:0016020	Membrane	IEA	cellular_component
GO:0019215	Intermediate filament binding	IEA	molecular_function
GO:0019901	Protein kinase binding	IEA	molecular_function
GO:0021766	Hippocampus development	IEA	biological_process
GO:0032587	Ruffle membrane	IDA	cellular_component
GO:0033574	Response to testosterone	IEA	biological_process
GO:0035690	Cellular response to drug	IEA	biological_process
GO:0042802	Identical protein binding	IPI	molecular_function
GO:0042981	Regulation of apoptotic process	TAS	biological_process
GO:0043015	Gamma-tubulin binding	IEA	molecular_function
GO:0043024	Ribosomal small subunit binding	IPI	molecular_function
GO:0043388	Positive regulation of DNA binding	IDA	biological_process
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0048471	Perinuclear region of cytoplasm	IEA	cellular_component
GO:0050679	Positive regulation of epithelial cell proliferation	IMP	biological_process
GO:0051591	Response to cAMP	IEA	biological_process
GO:0055086	Nucleobase-containing small molecule metabolic process	TAS	biological_process
GO:0071333	Cellular response to glucose stimulus	IEA	biological_process
GO:0071398	Cellular response to fatty acid	IEA	biological_process
GO:0090305	Nucleic acid phosphodiester bond hydrolysis	IDA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.2947727822	0.0897462027	0.9941997951	0.5689329961

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.7535904949
GSE13712_SHEAR	Up	0.8302571921
GSE13712_STATIC	Up	0.5908143967
GSE19018	Down	-0.6966405011
GSE19899_A1	Up	0.1800002058
GSE19899_A2	Down	-0.2620072549
PubMed_21979375_A1	Down	-0.2611729664
PubMed_21979375_A2	Down	-0.2779314218
GSE35957	Down	-0.6854205490
GSE36640	Down	-0.3952424753
GSE54402	Up	0.2935595750
GSE9593	Down	-0.1355997378
GSE43922	-	-
GSE24585	-	-
GSE37065	-	-
GSE28863_A1	Down	-0.5975875739
GSE28863_A2	Down	-0.2557656195
GSE28863_A3	Down	-0.0994063803
GSE28863_A4	Up	0.2426069602
GSE48662	Down	-0.3066925597

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
2'-Deoxyguanosine-5'-Triphosphate	DB02181	EXPT01184
Selenocysteine	DB02345	EXPT01033
2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate	DB02569	EXPT01096
Adenosine Phosphonoacetic Acid	DB02607	EXPT02938
2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate	DB02887	EXPT01098
Thymidine-5'- Diphosphate	DB03103	EXPT03136
2'-Deoxyguanosine-5'-Diphosphate	DB03491	EXPT01179
Fudp	DB04068	EXPT01512
Guanosine-5'-Diphosphate	DB04315	EXPT01573
3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate	DB04366	EXPT00161
3'-Azido-3'-Deoxythymidine-5'-Diphosphate	DB04542	EXPT00601

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for NME1

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )