HCSGD entry for NKX3-1

1. General information

Official gene symbolNKX3-1
Entrez ID4824
Gene full nameNK3 homeobox 1
Other gene symbolsBAPX2 NKX3 NKX3.1 NKX3A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000976Transcription regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0001047Core promoter bindingIDAmolecular_function
GO:0001656Metanephros developmentIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDA NASmolecular_function
GO:0004882Androgen receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005634NucleusIC IDA NAScellular_component
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0007431Salivary gland developmentISSbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processIDAmolecular_function
GO:0010628Positive regulation of gene expressionIDA IMPbiological_process
GO:0010629Negative regulation of gene expressionIDAbiological_process
GO:0010942Positive regulation of cell deathIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0030284Estrogen receptor activityIDAmolecular_function
GO:0030295Protein kinase activator activityIDAmolecular_function
GO:0030331Estrogen receptor bindingIDAmolecular_function
GO:0030521Androgen receptor signaling pathwayIDAbiological_process
GO:0033574Response to testosteroneISSbiological_process
GO:0035690Cellular response to drugIEPbiological_process
GO:0035907Dorsal aorta developmentIEAbiological_process
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043401Steroid hormone mediated signaling pathwayIDAbiological_process
GO:0043491Protein kinase B signalingIMPbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043569Negative regulation of insulin-like growth factor receptor signaling pathwayISSbiological_process
GO:0043621Protein self-associationIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMP ISSbiological_process
GO:0045930Negative regulation of mitotic cell cycleIDAbiological_process
GO:0045931Positive regulation of mitotic cell cycleIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeISSbiological_process
GO:0050680Negative regulation of epithelial cell proliferationISSbiological_process
GO:0051781Positive regulation of cell divisionIMPbiological_process
GO:0060037Pharyngeal system developmentIEAbiological_process
GO:0060442Branching involved in prostate gland morphogenesisISSbiological_process
GO:0060664Epithelial cell proliferation involved in salivary gland morphogenesisISSbiological_process
GO:0060770Negative regulation of epithelial cell proliferation involved in prostate gland developmentISSbiological_process
GO:0071347Cellular response to interleukin-1IEPbiological_process
GO:0071356Cellular response to tumor necrosis factorIEPbiological_process
GO:0071383Cellular response to steroid hormone stimulusIDAbiological_process
GO:0071456Cellular response to hypoxiaIDAbiological_process
GO:0071850Mitotic cell cycle arrestIDAbiological_process
GO:0071899Negative regulation of estrogen receptor bindingIDAbiological_process
GO:0097162MADS box domain bindingIEAmolecular_function
GO:2000836Positive regulation of androgen secretionIDAbiological_process
GO:2001022Positive regulation of response to DNA damage stimulusIDAbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIDAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15337810110.89976897910.77996389421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1746484051
GSE13712_SHEARDown-0.4266868055
GSE13712_STATICUp0.0598968194
GSE19018Down-0.1321165994
GSE19899_A1Up0.0941957760
GSE19899_A2Up0.2650940773
PubMed_21979375_A1Down-0.0239340993
PubMed_21979375_A2Up0.2468932034
GSE35957Down-0.4805781578
GSE36640Up0.1154665902
GSE54402Up0.9834668784
GSE9593Up0.1270087024
GSE43922Up0.0781802128
GSE24585Up0.1773949804
GSE37065Up0.1760419962
GSE28863_A1Down-0.0783280858
GSE28863_A2Down-0.0229349428
GSE28863_A3Up0.2988440105
GSE28863_A4Up0.0518674661
GSE48662Up0.1357744716

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024883MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026366MicroarrayFunctional MTI (Weak)19074876
hsa-miR-92a-3pMIMAT0000092MIRT049849CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.