HCSGD entry for NINJ1
1. General information
| Official gene symbol | NINJ1 |
|---|---|
| Entrez ID | 4814 |
| Gene full name | ninjurin 1 |
| Other gene symbols | NIN1 NINJURIN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0042246 | Tissue regeneration | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0026637552 | 0.8941412446 | 0.1391505929 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9111795973 |
| GSE13712_SHEAR | Up | 0.2788712532 |
| GSE13712_STATIC | Up | 0.5956509212 |
| GSE19018 | Down | -0.1952127988 |
| GSE19899_A1 | Up | 0.1911409997 |
| GSE19899_A2 | Up | 2.0770406503 |
| PubMed_21979375_A1 | Up | 1.6889248866 |
| PubMed_21979375_A2 | Up | 2.7173357274 |
| GSE35957 | Down | -0.7843878107 |
| GSE36640 | Up | 0.4544021902 |
| GSE54402 | Up | 1.1135704190 |
| GSE9593 | Down | -0.1840651478 |
| GSE43922 | Up | 0.4998492493 |
| GSE24585 | Up | 0.1412926018 |
| GSE37065 | Up | 0.5885060865 |
| GSE28863_A1 | Up | 0.0382103539 |
| GSE28863_A2 | Down | -0.4416300678 |
| GSE28863_A3 | Down | -0.1575172095 |
| GSE28863_A4 | Down | -0.0261123013 |
| GSE48662 | Up | 0.2446289350 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-107 | MIMAT0000104 | MIRT026972 | Microarray | Functional MTI (Weak) | 20489155 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23690620 | Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality |
| 23690620 | The nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a homophilic adhesion molecule and involved in nerve regeneration |
| 23690620 | Interestingly, Ninj1 is found to be overexpressed in human cancer, but its role in tumorigenesis is not clear |
| 23690620 | Here, we found that Ninj1 is transcriptionally regulated by p53 and can be induced by DNA damage in a p53-dependent manner |
| 23690620 | We also found that knockout or knockdown of Ninj1 increases p53 expression potentially through enhanced p53 mRNA translation |
| 23690620 | In addition, we found that Ninj1 deficiency suppresses cell proliferation but enhances apoptosis and premature senescence in a p53-dependent manner |
| 23690620 | Taken together, we provided evidence that Ninj1 is a p53 target and modulates p53 mRNA translation and p53-dependent premature senescence, cell proliferation, apoptosis, and radiation-induced mortality in vitro and in vivo |
| 23690620 | Thus, we postulate that as a membrane adhesion molecule, Ninj1 is an ideal target to regulate p53 activity via the p53-Ninj1 loop |
| 15464245 | Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells |
| 15464245 | BACKGROUND/AIMS: Ninjurin1 is a novel adhesion molecule that has a role in promoting nerve regeneration |
| 15464245 | Although ninjurin1 is ubiquitously expressed in various human tissues, including the liver, the biologic functions of ninjurin1 in tissues other than the nervous system remain unknown |
| 15464245 | The aim of this study was to investigate the function of ninjurin1 in hepatocytes |
| 15464245 | METHODS: The effect of ninjurin1 overexpression was examined in Huh-7 hepatoma cells |
| 15464245 | Ninjurin1 expression was examined by Western blot in human hepatocellular carcinoma tissues as well as their adjacent liver tissues |
| 15464245 | The levels of ninjurin1 expression were higher in hepatocellular carcinoma tissues than those in adjacent liver tissues |
| 15464245 | CONCLUSIONS: The present study provides the first evidence that ninjurin1 is able to induce the senescence program |
| 15464245 | Ninjurin1 may be involved in the regulation of cellular senescence in the liver during carcinogenesis |
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