HCSGD entry for TONSL
1. General information
| Official gene symbol | TONSL |
|---|---|
| Entrez ID | 4796 |
| Gene full name | tonsoku-like, DNA repair protein |
| Other gene symbols | IKBR NFKBIL2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000724 | Double-strand break repair via homologous recombination | IMP | biological_process |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005662 | DNA replication factor A complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0031297 | Replication fork processing | IMP | biological_process |
| GO:0035101 | FACT complex | IDA | cellular_component |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0042555 | MCM complex | IDA | cellular_component |
| GO:0042994 | Cytoplasmic sequestering of transcription factor | TAS | biological_process |
| GO:0043596 | Nuclear replication fork | IDA | cellular_component |
| GO:2001141 | Regulation of RNA biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9711234642 | 0.1770072224 | 0.9999902473 | 0.8140847632 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0630397493 |
| GSE13712_SHEAR | Down | -0.0815483736 |
| GSE13712_STATIC | Down | -0.0126743596 |
| GSE19018 | Up | 0.0051985819 |
| GSE19899_A1 | Down | -0.0413105969 |
| GSE19899_A2 | Down | -0.2901658094 |
| PubMed_21979375_A1 | Down | -0.1776118793 |
| PubMed_21979375_A2 | Down | -0.1745386883 |
| GSE35957 | Down | -0.1981786106 |
| GSE36640 | Down | -0.1082948062 |
| GSE54402 | Down | -0.0439681359 |
| GSE9593 | Down | -0.1036553324 |
| GSE43922 | Up | 0.0501070908 |
| GSE24585 | Down | -0.0638859746 |
| GSE37065 | Up | 0.0094374875 |
| GSE28863_A1 | Down | -0.2826102187 |
| GSE28863_A2 | Down | -0.1376088173 |
| GSE28863_A3 | Down | -0.1801142996 |
| GSE28863_A4 | Down | -0.0336404402 |
| GSE48662 | Down | -0.1076760118 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT039762 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044557 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049574 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
