HCSGD entry for NFIC
1. General information
| Official gene symbol | NFIC |
|---|---|
| Entrez ID | 4782 |
| Gene full name | nuclear factor I/C (CCAAT-binding transcription factor) |
| Other gene symbols | CTF CTF5 NF-I NFI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA IGI | biological_process |
| GO:0001159 | Core promoter proximal region DNA binding | IEA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0042475 | Odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1359660005 | 0.1766560427 | 0.7443180287 | 0.8133223194 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3013361532 |
| GSE13712_SHEAR | Down | -0.6360121864 |
| GSE13712_STATIC | Down | -0.0703224405 |
| GSE19018 | Up | 0.2487663138 |
| GSE19899_A1 | Down | -0.4813524649 |
| GSE19899_A2 | Up | 0.4048957033 |
| PubMed_21979375_A1 | Down | -0.2175120390 |
| PubMed_21979375_A2 | Up | 0.3069945207 |
| GSE35957 | Down | -0.3018734454 |
| GSE36640 | Down | -0.4327051803 |
| GSE54402 | Down | -0.2903317986 |
| GSE9593 | Up | 0.0709278611 |
| GSE43922 | Down | -0.1747443074 |
| GSE24585 | Down | -0.0016620805 |
| GSE37065 | Down | -0.1867800940 |
| GSE28863_A1 | Up | 1.2927575621 |
| GSE28863_A2 | Up | 0.9558054889 |
| GSE28863_A3 | Up | 0.4326654719 |
| GSE28863_A4 | Down | -0.0277593545 |
| GSE48662 | Up | 0.1654219808 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002601 | Proteomics | Functional MTI (Weak) | 18668037 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002601 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040932 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042760 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10585259 | NF-Y, also termed CBF, is a major CCAAT-binding transcription factor that specifically recognizes the consensus sequence 5'-CTGATTGGYYRR-3 or 5'-YYRRCCAATCAG-3' (Y = pyrimidines and R = purines) present in the promoter region of many constitutive, inducible, and cell-cycle-dependent eukaryotic genes |
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