HCSGD entry for NFIB

1. General information

Official gene symbolNFIB
Entrez ID4781
Gene full namenuclear factor I/B
Other gene symbolsCTF HMGIC/NFIB NF-I/B NF1-B NFI-B NFI-RED NFIB2 NFIB3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001106RNA polymerase II transcription corepressor activityIDAmolecular_function
GO:0002062Chondrocyte differentiationISSbiological_process
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0010001Glial cell differentiationISSbiological_process
GO:0021740Principal sensory nucleus of trigeminal nerve developmentISSbiological_process
GO:0021960Anterior commissure morphogenesisISSbiological_process
GO:0030902Hindbrain developmentIEAbiological_process
GO:0043392Negative regulation of DNA bindingIDAbiological_process
GO:0044300Cerebellar mossy fiberISScellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0060486Clara cell differentiationISSbiological_process
GO:0060509Type I pneumocyte differentiationISSbiological_process
GO:0060510Type II pneumocyte differentiationISSbiological_process
GO:0061141Lung ciliated cell differentiationISSbiological_process
GO:0071679Commissural neuron axon guidanceISSbiological_process
GO:2000791Negative regulation of mesenchymal cell proliferation involved in lung developmentISSbiological_process
GO:2000795Negative regulation of epithelial cell proliferation involved in lung morphogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89014831880.03624980050.99999024730.3584263711

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3227008831
GSE13712_SHEARDown-0.0683339491
GSE13712_STATICDown-0.2205158793
GSE19018Down-0.1133113474
GSE19899_A1Down-0.0469991784
GSE19899_A2Up0.2263420706
PubMed_21979375_A1Down-0.2082139548
PubMed_21979375_A2Down-0.5164122072
GSE35957Up0.1615581567
GSE36640Down-0.2928618056
GSE54402Down-0.1791801876
GSE9593Down-0.8222669308
GSE43922Down-0.3091697950
GSE24585Down-0.1127984892
GSE37065Down-0.3709345094
GSE28863_A1Up0.3615899025
GSE28863_A2Down-0.3436287936
GSE28863_A3Up0.3740691743
GSE28863_A4Up0.2306316584
GSE48662Down-0.2164848119

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT002090Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI18384814
hsa-miR-130b-3pMIMAT0000691MIRT020191SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT022459Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-192-5pMIMAT0000222MIRT026339MicroarrayFunctional MTI (Weak)19074876
hsa-miR-93-5pMIMAT0000093MIRT028056SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031194SequencingFunctional MTI (Weak)20371350
hsa-miR-92a-3pMIMAT0000092MIRT049176CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT00000761hsa-miR-21{Western blot}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}18384814
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23496142These two cell-cycle regulators are indirectly regulated by miR-21 via its validated direct targets NFIB (Nuclear factor 1 B-type), a transcriptional inhibitor of p21(CIP) (1) , and CDC25A, which regulates CDK2 activity by dephosphorylation
23496142Knock-down of either NFIB or CDC25A shows a phenocopy of over-expressing miR-21 in regard to cell-cycle arrest
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