HCSGD entry for NFATC2

1. General information

Official gene symbolNFATC2
Entrez ID4773
Gene full namenuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Other gene symbolsNFAT1 NFATP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001816Cytokine productionIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA TAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006974Cellular response to DNA damage stimulusIMPbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0016477Cell migrationIDAbiological_process
GO:0030529Ribonucleoprotein complexIEAcellular_component
GO:0030890Positive regulation of B cell proliferationIMPbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042493Response to drugIMPbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0050853B cell receptor signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40772543600.67113470990.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2045039018
GSE13712_SHEARDown-0.1769540823
GSE13712_STATICDown-0.1909809061
GSE19018Down-0.1717231065
GSE19899_A1Up0.0487304434
GSE19899_A2Down-0.2276741046
PubMed_21979375_A1Down-0.0267552019
PubMed_21979375_A2Down-0.0184269920
GSE35957Up0.0306119198
GSE36640Down-0.2061409745
GSE54402Up0.4782794793
GSE9593Down-0.2034277964
GSE43922Up0.0443925854
GSE24585Up0.4278292802
GSE37065Up0.2915331402
GSE28863_A1Down-0.2153877358
GSE28863_A2Up0.0288736417
GSE28863_A3Up0.2402735723
GSE28863_A4Up0.0155042250
GSE48662Up0.1096948006

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-184MIMAT0000454MIRT005078Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19286996
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-184MIMAT00004541hsa-miR-184{Western blot}{downregulation by anti-miRNA oligonucleotide}19286996
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.