HCSGD entry for NF2

1. General information

Official gene symbolNF2
Entrez ID4771
Gene full nameneurofibromin 2 (merlin)
Other gene symbolsACN BANF SCH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001707Mesoderm formationIEAbiological_process
GO:0001953Negative regulation of cell-matrix adhesionTASbiological_process
GO:0003779Actin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005912Adherens junctionIEAcellular_component
GO:0006469Negative regulation of protein kinase activityIEAbiological_process
GO:0007398Ectoderm developmentIEAbiological_process
GO:0008156Negative regulation of DNA replicationIMPbiological_process
GO:0008285Negative regulation of cell proliferationIDA IMPbiological_process
GO:0014010Schwann cell proliferationIMPbiological_process
GO:0019898Extrinsic component of membraneIEAcellular_component
GO:0022408Negative regulation of cell-cell adhesionIDAbiological_process
GO:0030027LamellipodiumIEAcellular_component
GO:0030036Actin cytoskeleton organizationIMPbiological_process
GO:0030336Negative regulation of cell migrationTASbiological_process
GO:0030864Cortical actin cytoskeletonIEAcellular_component
GO:0031527Filopodium membraneIEAcellular_component
GO:0032154Cleavage furrowIEAcellular_component
GO:0032587Ruffle membraneIEAcellular_component
GO:0035330Regulation of hippo signalingIMPbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042518Negative regulation of tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0042524Negative regulation of tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0043409Negative regulation of MAPK cascadeIEAbiological_process
GO:0045216Cell-cell junction organizationIEAbiological_process
GO:0046426Negative regulation of JAK-STAT cascadeIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051496Positive regulation of stress fiber assemblyIMPbiological_process
GO:0070306Lens fiber cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85758360240.06129394400.99999024730.4665465298

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1661110391
GSE13712_SHEARUp0.0695124811
GSE13712_STATICUp0.5479386267
GSE19018Down-0.0971004420
GSE19899_A1Down-0.1359282866
GSE19899_A2Down-0.1718698088
PubMed_21979375_A1Down-0.7150698051
PubMed_21979375_A2Down-0.5421691616
GSE35957Down-0.1263460177
GSE36640Up0.0092082023
GSE54402Down-0.2834819883
GSE9593Up0.0416096782
GSE43922Down-0.3486362053
GSE24585Down-0.3533202977
GSE37065Down-0.3805368858
GSE28863_A1Up0.1029116876
GSE28863_A2Up0.6687345859
GSE28863_A3Down-0.3992698318
GSE28863_A4Up0.1144455200
GSE48662Down-0.1909980407

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7a-5pMIMAT0000062MIRT001853Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;OtherFunctional MTI17220301
hsa-miR-193b-3pMIMAT0002819MIRT016579MicroarrayFunctional MTI (Weak)20304954
hsa-miR-1229-3pMIMAT0005584MIRT036332CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047749CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-let-7a-5pMIMAT00000621hsa-let-7a{Western blot}{underexpression by anti-miRNA oligonucleotides}17220301
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25909290Evaluation of NF2 co-expressed genes further confirms the enrichment of chromosome 22 regions
25909290Finally, systematic integration of chromosome 22 genes with interactome and NF2 co-expression data identifies key candidate genes
17962031Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth
17962031Meningiomas, common tumors arising from arachnoidal cells of the meninges, may occur sporadically, or in association with the inherited disorder, neurofibromatosis 2 (NF2)
17962031Most sporadic meningiomas result from NF2 inactivation, resulting in loss of tumor suppressor merlin, implicated in regulating membrane-cytoskeletal organization
17962031To investigate merlin function in an authentic target cell type for NF2 tumor formation, we established primary cultures from genetically-matched meningioma and normal arachnoidal tissues
17962031Merlin suppression by RNAi in arachnoidal cells replicated merlin-deficient meningioma features, thus establishing these cell systems as disease-relevant models for studying NF2 tumorigenesis
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