HCSGD entry for NEU1
1. General information
| Official gene symbol | NEU1 |
|---|---|
| Entrez ID | 4758 |
| Gene full name | sialidase 1 (lysosomal sialidase) |
| Other gene symbols | NANH NEU SIAL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004308 | Exo-alpha-sialidase activity | IDA IEA | molecular_function |
| GO:0005764 | Lysosome | IDA IEA | cellular_component |
| GO:0005765 | Lysosomal membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0009313 | Oligosaccharide catabolic process | IMP | biological_process |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0052794 | Exo-alpha-(2->3)-sialidase activity | IEA | molecular_function |
| GO:0052795 | Exo-alpha-(2->6)-sialidase activity | IEA | molecular_function |
| GO:0052796 | Exo-alpha-(2->8)-sialidase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0003828806 | 0.9786803161 | 0.0518261307 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.8357539058 |
| GSE13712_SHEAR | Up | 0.0624908809 |
| GSE13712_STATIC | Up | 0.2749859771 |
| GSE19018 | Up | 0.1020752395 |
| GSE19899_A1 | Up | 1.0505070166 |
| GSE19899_A2 | Up | 1.3181310341 |
| PubMed_21979375_A1 | Up | 1.4765247677 |
| PubMed_21979375_A2 | Up | 1.3999428770 |
| GSE35957 | Down | -0.2238056735 |
| GSE36640 | Up | 0.9400625197 |
| GSE54402 | Up | 0.7455033044 |
| GSE9593 | Up | 1.0127148700 |
| GSE43922 | Up | 0.8542200164 |
| GSE24585 | Up | 0.9526451706 |
| GSE37065 | Up | 0.2827885067 |
| GSE28863_A1 | Down | -0.0481162565 |
| GSE28863_A2 | Up | 0.9995396604 |
| GSE28863_A3 | Down | -0.5812424302 |
| GSE28863_A4 | Down | -0.3811548759 |
| GSE48662 | Up | 0.1496495652 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020584 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 7518456 | The release of the radioactivity from the anti-human IgG-bound senescent cells was enhanced by incubation with band 3 oligosaccharides but not by those digested with endo-beta-galactosidase or neuraminidase |
| 8115995 | Platelets were isolated from blood of baboons and treated with neuraminidase to remove platelet membrane sialic acid, a process which artificially ages the platelets |
| 8115995 | Removal of sialic acid by neuraminidase did not affect the aggregation of platelets by agonists in vitro, nor their sites of sequestration |
| 6490404 | This can be mimicked by neuraminidase and protease treatment of erythrocytes in vitro |
| 6363100 | Heat-eluted IgG (He-IgG) prepared from senescent red blood cells was capable of binding to either heat-treated old platelets or Vibrio cholerae neuraminidase (VCN)-treated young platelets, suggesting expression of a common age-dependent antigen on the senescent red blood cells and old platelets |
| 7055615 | The decrease in sialic acid biosynthesis in differentiated erythroleukemia cells was reflected by an 83% decrease in the amount of radioactively-labeled sialic acid released by neuraminidase treatment of cells exposed to dimethylsulfoxide |
| 7470642 | The efficacy of neuraminidase treatment in studies on red cell aging |
| 29906 | Anomalous electrophoretic properties of neuraminidase treated human erythrocytes |
| 29906 | Desialylation of human red blood cells (RBC) by Vibrio cholerae neuraminidase (VCN) was found to produce cells with electrophoretic properties which were inconsistent with the view of simple loss of N-acetylneuraminic acid (NANA) as the sole effect of VCN treatment |
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