HCSGD entry for NEK3
1. General information
| Official gene symbol | NEK3 |
|---|---|
| Entrez ID | 4752 |
| Gene full name | NIMA-related kinase 3 |
| Other gene symbols | HSPK36 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | NAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | ISS | biological_process |
| GO:0007067 | Mitosis | NAS | biological_process |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9892105809 | 0.0044227309 | 0.9999902473 | 0.1353612791 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0515055843 |
| GSE13712_SHEAR | Up | 0.0437688762 |
| GSE13712_STATIC | Down | -0.3945295139 |
| GSE19018 | Down | -0.0783888289 |
| GSE19899_A1 | Down | -0.1864752816 |
| GSE19899_A2 | Down | -1.0653240106 |
| PubMed_21979375_A1 | Down | -2.1913187766 |
| PubMed_21979375_A2 | Down | -1.4164585086 |
| GSE35957 | Down | -0.8577206262 |
| GSE36640 | Down | -1.1749130304 |
| GSE54402 | Down | -0.2019069608 |
| GSE9593 | Down | -0.1151322942 |
| GSE43922 | Down | -0.1148281778 |
| GSE24585 | Down | -0.1579198979 |
| GSE37065 | Up | 0.1914509011 |
| GSE28863_A1 | Up | 0.0002997203 |
| GSE28863_A2 | Down | -0.2127019731 |
| GSE28863_A3 | Down | -0.4079377029 |
| GSE28863_A4 | Up | 0.1050650784 |
| GSE48662 | Down | -0.6830816529 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027849 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047278 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
