HCSGD entry for NDUFS4

1. General information

Official gene symbolNDUFS4
Entrez ID4724
Gene full nameNADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
Other gene symbolsAQDQ CI-18
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001932Regulation of protein phosphorylationIMPbiological_process
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneTAScellular_component
GO:0005747Mitochondrial respiratory chain complex IIDA IMPcellular_component
GO:0006120Mitochondrial electron transport, NADH to ubiquinoneNASbiological_process
GO:0007420Brain developmentIMPbiological_process
GO:0008137NADH dehydrogenase (ubiquinone) activityIMPmolecular_function
GO:0016651Oxidoreductase activity, acting on NAD(P)HIEAmolecular_function
GO:0019933CAMP-mediated signalingIMPbiological_process
GO:0022900Electron transport chainIEAbiological_process
GO:0022904Respiratory electron transport chainTASbiological_process
GO:0032981Mitochondrial respiratory chain complex I assemblyIMPbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045333Cellular respirationIMPbiological_process
GO:0048146Positive regulation of fibroblast proliferationIMPbiological_process
GO:0051591Response to cAMPIMPbiological_process
GO:0072593Reactive oxygen species metabolic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90306315110.32758716990.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0266058008
GSE13712_SHEARUp0.0852126729
GSE13712_STATICDown-0.0185228416
GSE19018Up0.2348414716
GSE19899_A1Down-0.0280241946
GSE19899_A2Down-0.0142108754
PubMed_21979375_A1Down-0.0309771342
PubMed_21979375_A2Up0.0085235585
GSE35957Down-0.0682434241
GSE36640Down-0.0665119606
GSE54402Down-0.0740328760
GSE9593Down-0.2282800747
GSE43922Down-0.0439125174
GSE24585Down-0.3342411239
GSE37065Down-0.0203724367
GSE28863_A1Up0.3016132905
GSE28863_A2Up0.0562710966
GSE28863_A3Down-0.2443041313
GSE28863_A4Down-0.0905052256
GSE48662Down-0.1764799288

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023936ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23514110Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4
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