HCSGD entry for ACLY
1. General information
| Official gene symbol | ACLY |
|---|---|
| Entrez ID | 47 |
| Gene full name | ATP citrate lyase |
| Other gene symbols | ACL ATPCL CLATP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003878 | ATP citrate synthase activity | IEA TAS | molecular_function |
| GO:0004775 | Succinate-CoA ligase (ADP-forming) activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006101 | Citrate metabolic process | TAS | biological_process |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0008610 | Lipid biosynthetic process | IDA | biological_process |
| GO:0009346 | Citrate lyase complex | TAS | cellular_component |
| GO:0015936 | Coenzyme A metabolic process | TAS | biological_process |
| GO:0019432 | Triglyceride biosynthetic process | TAS | biological_process |
| GO:0031325 | Positive regulation of cellular metabolic process | TAS | biological_process |
| GO:0035338 | Long-chain fatty-acyl-CoA biosynthetic process | TAS | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044262 | Cellular carbohydrate metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048037 | Cofactor binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1311491851 | 0.5400637704 | 0.7350889480 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2500866050 |
| GSE13712_SHEAR | Up | 0.1973712055 |
| GSE13712_STATIC | Up | 0.0147814527 |
| GSE19018 | Up | 0.0677330373 |
| GSE19899_A1 | Up | 0.7094685013 |
| GSE19899_A2 | Up | 0.1251481379 |
| PubMed_21979375_A1 | Down | -0.0243926753 |
| PubMed_21979375_A2 | Up | 0.5471959270 |
| GSE35957 | Down | -0.3450211167 |
| GSE36640 | Up | 0.3938212545 |
| GSE54402 | Up | 0.1590747188 |
| GSE9593 | Up | 0.2193640725 |
| GSE43922 | Up | 0.4519888215 |
| GSE24585 | Down | -0.4138701533 |
| GSE37065 | Down | -0.0234108580 |
| GSE28863_A1 | Up | 0.1034736820 |
| GSE28863_A2 | Up | 0.4579156402 |
| GSE28863_A3 | Down | -0.4327028524 |
| GSE28863_A4 | Down | -0.0109108133 |
| GSE48662 | Down | -0.6926485154 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320b | MIMAT0005792 | MIRT036222 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036343 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037071 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-3p | MIMAT0004555 | MIRT038673 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038850 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039123 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040866 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042069 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042918 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044080 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045416 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045906 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047450 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049373 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25367309 | ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate |
| 25367309 | Up-regulation of ACLY in various types of tumors enhances fatty acid synthesis and supplies excess acetyl CoA for histone acetylation |
| 25367309 | In this study, we found that ACLY knockdown in primary human cells triggers cellular senescence and activation of tumor suppressor p53 |
| 25367309 | Provision of acetyl CoA to ACLY knockdown cells did not alleviate ACLY silencing-induced p53 activation, suggesting an independent role for ACLY activity |
| 25367309 | In cancer cells, ACLY silencing-induced p53 activation facilitated DNA damage-induced cell death |
| 24396695 | Finally, blocking lipogenesis with fatty acid synthase inhibitors (cerulenin and C75) and siRNA-mediated silencing of SREBP1 and ATP citrate lyase (ACL) significantly attenuated GSK3 inhibition-induced senescence |
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